Gene interactions and pathways from curated databases and text-mining

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ADAM17 — EGF

Pathways - manually collected, often from reviews:

  • Reactome Reaction: ADAM17 → EGF (reaction)

Text-mined interactions from Literome

Shah et al., Trends Pharmacol Sci 2006 (Kidney Diseases) : TACE dependent EGF receptor activation in angiotensin-II induced kidney disease
Zhang et al., Proc Natl Acad Sci U S A 2006 : Phosphorylation of TNF-alpha converting enzyme by gastrin releasing peptide induces amphiregulin release and EGF receptor activation
Melenhorst et al., Kidney Int 2006 (Disease Progression...) : ADAM mediated EGF receptor activation is crucial in the development of renal pathology