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CCR2 — NFKB1

Text-mined interactions from Literome

Yang et al., J Immunol 2001 : In addition to formyl peptide receptor, Galpha(16) also enhanced NF-kappaB activation by the C5a and C3a receptors, and by CXC chemokine receptor 2 and CCR8
Quinones et al., Mol Cell Neurosci 2008 (Demyelinating Diseases...) : Using an in vitro system we demonstrate that expression of CCR2 was functional in astrocytes and that signaling via this receptor lead to activation of NF-kB and Akt and was associated with increased astrocyte survival
Binder et al., Nat Med 2009 (Bone Resorption...) : In normal mice, activation of CCR2 in osteoclast progenitor cells results in both nuclear factor-kappaB (NF-kappaB) and extracellular signal related kinase 1 and 2 ( ERK1/2 ) signaling but not that of p38 mitogen activated protein kinase or c-Jun N-terminal kinase
Jimenez et al., J Immunol 2010 (Leishmaniasis, Cutaneous) : We postulated that CCR2-driven activation of the transcription factor NF-kappaB plays a critical role in dendritic cell ( DC ) maturation ( e.g., migration, costimulation, and IL-12p70 production ), necessary for the generation of protective immune responses against the intracellular pathogen Leishmania major ... Collectively, our data point to an important role for CCR2-driven activation of NF-kappaB in the regulation of DC/LC maturation processes that regulate protective immunity against intracellular pathogens