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CA2 — TACR1

Text-mined interactions from Literome

Jun et al., Eur J Pharmacol 2004 : Our results demonstrate that substance P may modulate intestinal motility by acting on the interstitial cells of Cajal by activating nonselective cation channels via the release of intracellular Ca2+ induced by tachykinin NK1 receptor stimulation
Lin et al., J Biomed Sci 2005 (Calcium Signaling) : Blockade of both InsP3 receptor and RyR enhances the Ca2+ influx through native Ca2+ channels in plasma membrane, which is crucial to Ca2+ signaling in response to NK1 receptor activation
Lai et al., Proc Natl Acad Sci U S A 2006 : When a plasmid containing the full-length NK-1R was introduced into undifferentiated THP-1 cells, exposure to SP triggered Ca2+ increase, demonstrating that the full-length NK-1R is required for SP-induced Ca2+ increase
McConalogue et al., Mol Biol Cell 1998 : SP caused 1 ) rapid NK1-R mediated increase in [Ca2+ ] i, which was transient and desensitized to repeated stimulation ; 2 ) internalization of the NK1-R into early endosomes containing SP ; and 3 ) rapid and transient redistribution of beta-arrestin-1 and -2 from the cytosol to the plasma membrane, followed by a striking redistribution of beta-arrestin-1 and -2 to endosomes containing the NK1-R and SP