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CA2 — GRP
Text-mined interactions from Literome
Slice et al., Receptors Channels 1998
:
In comparison with epithelial cells expressing wild-type GRPR, the GRPR-GFP expressing cells showed similar ligand binding affinity,
GRP stimulated
Ca2+ signaling, and GRP initiated internalization
Karlsson et al., Biochem Biophys Res Commun 2001
(Calcium Signaling) :
Direct cytoplasmic
CA(2+) responses to
gastrin releasing peptide in single beta cells
Woll et al., Cancer Res 1990
(Carcinoma, Small Cell...) :
It also blocked receptor mediated
Ca2+ mobilization
induced by vasopressin, bradykinin, cholecystokinin, galanin,
gastrin releasing peptide , and neurotensin
Karlsson et al., Peptides 1996
:
Furthermore, the
GRP induced increase in [
Ca2+ ] ic was potentiated by forskolin and impaired by activation of protein kinase C ( PKC ) by 12-O-tetradecanoyl-phorbol-13-acetate ( TPA )
Gregersen et al., Pancreas 1996
:
Similarly,
GRP increased 86Rb+ efflux from 86Rb ( + ) -prelabeled islets both in the presence and in the absence of extracellular
Ca2+ ( p < 0.001 )
Sharif et al., Mol Cell Endocrinol 1997
(Glioblastoma) :
Bombesin and
GRP induced the release of cytosolic
Ca2+ in a concentration dependent manner