Gene interactions and pathways from curated databases and text-mining

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BRCA1 — MRE11A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Paull et al., Proc Natl Acad Sci U S A 2001 : As a result of this binding, Brca1 inhibits the nucleolytic activities of the Mre11/Rad50/Nbs1 complex , an enzyme implicated in numerous aspects of double-strand break repair
Cousineau et al., Cancer Res 2005 (Breast Neoplasms...) : However, BRCA1 may regulate RAD51 in response to DNA damage or through its ability to interact with and regulate MRE11/RAD50/NBS1 (MRN) during the processing of DSBs into single-strand DNA ( ssDNA ) ends, prerequisite substrates for RAD51, or both ... However, BRCA1 may regulate RAD51 in response to DNA damage or through its ability to interact with and regulate MRE11/RAD50/NBS1 (MRN) during the processing of DSBs into single-strand DNA ( ssDNA ) ends, prerequisite substrates for RAD51, or both
Yang et al., PloS one 2008 (Adenocarcinoma...) : Oncogenic K-ras induced BASC accumulation and tumor growth were blocked by treatment with a small molecule PI3K inhibitor and enhanced by inactivation of phosphatase and tensin homologue deleted from chromosome 10, a negative regulator of PI3K
Dovey et al., Proc Natl Acad Sci U S A 2008 (Cell Transformation, Neoplastic...) : Abrogated lung cancer development and BASC self-renewal occur partially in a p19(ARF) dependent manner