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Ren et al., Arterioscler Thromb Vasc Biol 2000 : The present study demonstrated that treatment with antioxidants, butylated hydroxytoluene or vitamin E, blocked native LDL- and glycated LDL induced changes in PAI-1 and tPA generation in ECs ... Cotreatment with native or glycated HDL inhibited LDL induced or glycated LDL induced changes in PAI-1 and tPA generation in ECs ... The effects of antioxidants and HDL on LDL induced or its glycated LDL induced changes in the generation of PAI-1 and tPA were also found in cultured human coronary artery ECs
Beaudeux et al., Life Sci 2001 : Thus, the discordant effects of O2*-/HO* oxidized and copper oxidized LDL and Lp(a) on the endothelial releases of PAI-1 and tPA appeared to be due to qualitatively and/or quantitatively different formation of oxidized components by the two oxidation processes
Ren et al., J Clin Endocrinol Metab 2002 (Diabetes Mellitus...) : LDL from patients with type 1 or type 2 DM, and very low density lipoprotein ( VLDL ) from patients with type 2 DM induced significantly greater increases in the release of PAI-1 and more profound reduction in tPA generation from HUVEC compared with corresponding lipoproteins from healthy controls ( P < 0.05 or 0.01 ) ... The results of the present study suggest that LDL and VLDL from patients with DM reduce the generation of tPA and increase PAI-1 production through the activation of the PAI-1 promoter in vascular EC
Song et al., American journal of physiology. Renal physiology 2002 : We investigated the effects of low-density lipoprotein (LDL) on PA inhibitor-1 (PAI-1), urokinase-type PA (uPA), and tissue-type PA (tPA) in relationship to protein kinase C ( PKC ) in cultured human mesangial cells ( HMC ) ... LDL slightly increased tPA release at hours 24 and 48 but did not increase PA activity in culture medium ... The stimulatory effects of LDL on PAI-1, tPA , and uPA gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate ... In summary, LDL regulates PAI-1, uPA, and tPA in biphasic patterns in HMC, and the upregulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity
Shen et al., Mol Cell Biochem 2003 (Cardiovascular Diseases...) : LDL and lipoprotein ( a) [Lp(a ) ], another lipoprotein risk factor for CHD, reduced the generation of tPA from EC
Wang et al., Nat Med 2003 (Brain Ischemia) : Lipoprotein receptor mediated induction of matrix metalloproteinase by tissue plasminogen activator
Kim et al., J Neurol Sci 2004 (Intracranial Thrombosis) : We analyzed the effects of MM-LDL on brain capillary endothelial expression of plasminogen activator inhibitor-1 ( PAI-1 ), tissue-type plasminogen activator (tPA) , and thrombomodulin (TM)
Lai et al., Int J Cardiol 2005 (Hypercholesterolemia) : The total cholesterol, LDL-cholesterol and sVCAM-1 ( from 394.4+/-251.7 to 321.0+/-198.9 ng/ml, p < 0.05 ) all decreased significantly and the tPA ( from 9.47+/-3.57 to 11.62+/-3.99 ng/ml, p < 0.05 ) increased significantly after atorvastatin treatment
Klein et al., Ann N Y Acad Sci 2005 : Glycation does not alter LDL induced secretion of tissue plasminogen activator and plasminogen activator inhibitor-1 from human aortic endothelial cells ... Using LDL of different density subclasses, tPA and PAI-1 release in response to LDL from diabetic patients compared with control subjects did not differ when HAECs were incubated with LDLs of increasing density isolated from each subject pair
Levin et al., Arterioscler Thromb 1994 : We studied the effect of lipoprotein ( a) [Lp(a ) ], low-density lipoprotein (LDL) , and high-density lipoprotein ( HDL ) on tissue plasminogen activator (TPA) secretion from human endothelial cells
Zhang et al., Arterioscler Thromb Vasc Biol 1998 : The present study investigated the effect of glycated LDL on the production of PAI-1 and tPA in cultured human umbilical vein ECs ( HUVECs ) ... Glycated LDL did not significantly reduce the levels of tPA mRNA but attenuated de novo synthesis of tPA in ECs ... Treatment with 25 mmol/L aminoguanidine, an antioxidant and inhibitor of the formation of advanced glycation end products, during glycation normalized glycated LDL induced generation of PAI-1 and tPA in ECs