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POLI — TP53

Text-mined interactions from Literome

Budde et al., Oncogene 1999 : Transient transfection assays with a set of rDNA deletion mutants demonstrate that intergenic spacer sequences are dispensable and the minimal rDNA promoter is sufficient for p53 mediated repression of Pol I transcription ... Thus, repression of Pol I transcription by p53 may be a consequence of p53 induced growth arrest
Zhai et al., Mol Cell Biol 2000 : Moreover, it appears that p53 also suppresses RNA Pol I transcription ... We show that wild-type, but not mutant, p53 can repress Pol I transcription from a human rRNA gene promoter in cotransfection assays ... In summary, our results suggest that p53 represses RNA Pol I transcription by directly interfering with the assembly of a productive transcriptional machinery on the rRNA promoter