◀ Back to TP53
PARP15 — TP53
Text-mined interactions from Literome
Mandir et al., J Neurochem 2002
(Disease Models, Animal...) :
p53 is a target of the nuclear enzyme Poly ( ADP-ribose ) polymerase ( PARP ), and
PARP is
activated following DNA damage that occurs following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) -induced neurotoxicity
Watanabe et al., Biochem Biophys Res Commun 2004
:
Furthermore, in vitro,
PARP-1 inhibited phosphorylation of
p53 on serine 15 and ( 32 ) P-incorporation into p53 by ATM in a DNA dependent manner
Zhang et al., Clin Cancer Res 2006
(Melanoma...) :
This was characterized by lack of DNA fragmentation,
delayed externalization of phosphatidylserine, caspase and
p53 independence, and severe mitochondrial disruption, and was preceded by poly ( ADP ) ribose polymerase (
PARP ) activation and depletion of intracellular ATP, indicative of necrotic cell death
Canner et al., Br J Cancer 2009
(Rhabdomyosarcoma, Alveolar...) :
However, RD2 and RH30 RMS cells, as well as human normal skeletal muscle cells, showed a minimal increase in
p53 signalling and no
induction of cleaved
PARP and caspase-3
Lee et al., Oncol Rep 2010
(Adenocarcinoma...) :
In this study, we examined the chemoresistance to 5-Fluorouracil ( 5-FU ) using MCF-7 breast cancer MTS. 5-FU ( 400 microM ) induced apoptosis in MCF-7 cell monolayer as determined by HO/PI staining,
PARP cleavage,
p53 induction , Bax induction, and Bcl-2 down-regulation
Ferraz da Costa et al., PloS one 2012
(Breast Neoplasms...) :
The resveratrol induced cytotoxicity in these cells was partially mediated by
p53 and
involved the activation of caspases 9 and 7 and the cleavage of
PARP
Wesierska-Gadek et al., Cancer Res 1999
:
Here, we have investigated whether
PARP deficiency may
affect the expression and regulation of wild-type ( wt )
p53
Simbulan-Rosenthal et al., Biochem Biophys Res Commun 1998
(Burkitt Lymphoma) :
The
role of poly ( ADP-ribose ) polymerase (
PARP ), an abundant nuclear enzyme activated by DNA strand breaks, in the
p53 response to y-irradiation was investigated in Burkitt 's lymphoma AG876 cells stably transfected with an inducible PARP antisense construct