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MAGEA2 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAGEA2B, MAGEA2
—
TP53
(physical association, affinity chromatography technology)
Monte et al., Proc Natl Acad Sci U S A 2006*
-
IRef Biogrid Interaction:
MAGEA2B, MAGEA2
—
TP53
(direct interaction, pull down)
Monte et al., Proc Natl Acad Sci U S A 2006*
-
IRef Intact Interaction:
Complex of HDAC3-TP53-MAGEA2B-MAGEA2-MAGEA2B-MAGEA2-TP53-HDAC3
(association, anti tag coimmunoprecipitation)
Monte et al., Proc Natl Acad Sci U S A 2006*
-
IRef Intact Interaction:
Complex of TRIM28-TP53-MAGEA2B-MAGEA2
(association, pull down)
Doyle et al., Mol Cell 2010
-
IRef Intact Interaction:
MAGEA2B, MAGEA2
—
TP53
(physical association, anti tag coimmunoprecipitation)
Monte et al., Proc Natl Acad Sci U S A 2006*
-
IRef Intact Interaction:
MAGEA2B, MAGEA2
—
TP53
(physical association, anti bait coimmunoprecipitation)
Monte et al., Proc Natl Acad Sci U S A 2006*
-
IRef Intact Interaction:
MAGEA2B, MAGEA2
—
TP53
(physical association, pull down)
Monte et al., Proc Natl Acad Sci U S A 2006*
Text-mined interactions from Literome
Marcar et al., Cancer Res 2010
(Bone Neoplasms...) :
These data suggest that
Mage-A may
block the association of
p53 with its cognate sites in chromatin ... Consistent with this idea, silencing of
Mage-A expression leads to upregulation of several p53-responsive genes in a p53 dependent manner and
stimulates by several fold the interaction of
p53 with the p21, MDM2, and PUMA promoters
Weeraratne et al., Neuro Oncol 2011
(Cerebellar Neoplasms...) :
This decrease in
MAGE-A results in a concomitant increase in
p53 and its associated transcriptional targets, p21/WAF1/CIP1 and, importantly, miR-34a
Glazer et al., Arch Otolaryngol Head Neck Surg 2011
(Carcinoma, Squamous Cell...) :
Subsequently, transfection of
MAGEA2 induced a decrease in messenger RNA expression of the
p53 downstream targets CDKN1A and BAX and decreased G1 arrest in cells allowed to remain confluent for longer than 48 hours