Gene interactions and pathways from curated databases and text-mining

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GP5 — TP53

Text-mined interactions from Literome

Li et al., J Invest Dermatol 2000 (Melanoma) : We examined the effect of mutant p53 on camptothecin induced apoptosis and the expression of genes which are known to be involved in apoptosis or drug resistance, such as bcl-2, bax, bak, p21waf1, and P-glycoprotein
Han et al., Zhonghua Gan Zang Bing Za Zhi 2001 (Carcinoma, Hepatocellular...) : To test the hypothesis that wild-type p53 regulates the expression of p-glycoprotein
Zhan et al., J Biol Chem 2005 (Neovascularization, Pathologic) : Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation
Lee et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : With regard to cell cycle related proteins, UDN glycoprotein ( 50 µg/ml ) significantly suppressed the expression of p53 , p21, and p27, whereas it enhanced activity of cyclin D1/CDK4
Lee et al., J Cell Biochem 2011 : In the cell cycle related proteins, SJSZ glycoprotein ( 50 ?µg/ml ) significantly enhances the expression of p53 , p21, and p27, whereas it suppressed the activity of cyclin D1/CDK4
De Angelis et al., Br J Cancer 1995 (Aneuploidy...) : P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo