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GP5 — TP53
Text-mined interactions from Literome
Li et al., J Invest Dermatol 2000
(Melanoma) :
We examined the
effect of mutant
p53 on camptothecin induced apoptosis and the expression of genes which are known to be involved in apoptosis or drug resistance, such as bcl-2, bax, bak, p21waf1, and
P-glycoprotein
Han et al., Zhonghua Gan Zang Bing Za Zhi 2001
(Carcinoma, Hepatocellular...) :
To test the hypothesis that wild-type
p53 regulates the expression of
p-glycoprotein
Zhan et al., J Biol Chem 2005
(Neovascularization, Pathologic) :
Transcriptional repression of protein kinase Calpha via Sp1 by wild type
p53 is
involved in inhibition of multidrug resistance 1
P-glycoprotein phosphorylation
Lee et al., Naunyn Schmiedebergs Arch Pharmacol 2011
:
With regard to cell cycle related proteins, UDN
glycoprotein ( 50 µg/ml ) significantly
suppressed the expression of
p53 , p21, and p27, whereas it enhanced activity of cyclin D1/CDK4
Lee et al., J Cell Biochem 2011
:
In the cell cycle related proteins, SJSZ
glycoprotein ( 50 ?µg/ml ) significantly
enhances the expression of
p53 , p21, and p27, whereas it suppressed the activity of cyclin D1/CDK4
De Angelis et al., Br J Cancer 1995
(Aneuploidy...) :
P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not
regulated by mutant
p53 in vivo