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ETS1 — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: ETS1 → TP53 (transcriptional regulation, unknown) Hollenhorst et al., Genes Dev 2007
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TP53 — ETS1 (physical association, affinity chromatography technology) Lee et al., Brain Res 2008*
• IRef Biogrid Interaction: TP53 — ETS1 (physical association, affinity chromatography technology) Kim et al., Oncogene 2003*

Text-mined interactions from Literome

Gentiletti et al., Oncogene 2002 : Overexpression of exogenous p53 increases the intracellular levels of p54 product
Xu et al., EMBO J 2002 : Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells ... Furthermore, electrophoretic mobility shift assays and immunoprecipitations demonstrated that the presence of Ets1 was necessary for a CBP/p53 complex to be formed
Leong et al., Mol Cancer Res 2009 : p16(INK4a) elevation in p53 ( -/- ) cells is, at least partially, mediated by Ets1, a known positive regulator of p16(INK4a), as p53 deficiency up-regulated Ets1 through protein stabilization and knockdown of Ets1 down-regulated p16(INK4a) expression in p53 ( -/- ) mouse embryonic fibroblasts
Muscat et al., Oncol Rep 1997 : While these findings suggest that ETS is a possible inducer of altered p53 expression in lung adenocarcinoma in non-smokers, larger studies are needed to confirm this relationship