Van Gool et al., Nat Med 2009
:
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin dependent manner
Bauer et al., J Biol Chem 2012
(Inflammation...) :
In turn, TRPM2 and Ca ( 2+ ) are shown to be involved in SIRT6 induced TNF and IL8 expression ... SIRT6 increases the nuclear levels of the Ca ( 2+ ) -dependent transcription factor, nuclear factor of activated T cells ( NFAT ), and cyclosporin A, a calcineurin inhibitor that reduces NFAT activity, reduces TNF and IL8 expression in SIRT6 overexpressing cells
Jiang et al., Nature 2013
:
SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl lysine