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PTPRC — TNF
Text-mined interactions from Literome
Blank et al., J Immunol 2001
:
Costimulation with OKT-3 and IL-2 optimally
induced secretion of IFN-gamma,
TNF-alpha , and IL-5, which was not decreased by
CD45 signals
Spertini et al., Immunology 2004
:
CD45 engagement by monoclonal antibodies on human activated T cells
triggers tumour necrosis factor-alpha (TNF-alpha) gene transcription in an epitope-specific manner
Estoppey et al., Eur J Immunol 1996
:
Epitope-specific engagement of the protein tyrosine phosphatase
CD45 induces
tumor necrosis factor-alpha gene expression via transcriptional mechanisms ... We here demonstrate that engagement of
CD45 by monoclonal antibodies ( mAb ) on activated T cells
induces tumor necrosis factor (TNF)-alpha as well as TNF-beta, interleukin (IL)-2 and IL-3 gene expression ... Nuclear run-on transcription assays demonstrated that
CD45 cross linking
caused transcriptional activation of the
TNF-alpha gene ...
CD45 ligation
resulted in
TNF-alpha secretion
Brown et al., Diabetologia 1998
(Diabetes Mellitus, Type 1...) :
Lymphoid hyperplasia,
CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus
result from
TNF blockade in NOD -- > NOD-scid adoptive T cell transfer