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LPL — TNF

Text-mined interactions from Literome

Mamputu et al., Arterioscler Thromb Vasc Biol 1999 : Differentiation of human monocytes to monocyte derived macrophages is associated with increased lipoprotein lipase induced tumor necrosis factor-alpha expression and production : a process involving cell surface proteoglycans and protein kinase C ... Although heparinase totally abolished LPL induced TNFalpha production in human monocytes, this agent did not significantly inhibit LPL effect in human MDMs ... In contrast, treatment of MDMs with chondroitinase suppressed LPL induced TNFalpha production ... Taken together, these data suggest that ( 1 ) differentiation of human monocytes to MDMs is associated with increased LPL induced TNFalpha mRNA expression and production, ( 2 ) a protein kinase C-dependent pathway is involved in the induction of TNFalpha by LPL in these cells, and ( 3 ) LPL effect is mediated by cell surface proteoglycans ... As MDMs secrete LPL in the vascular wall, we propose that LPL , by acting as an autocrine activator of MDM function, may contribute to the high level of TNFalpha found in the atheromatous lesion
Tengku-Muhammad et al., Cytokine 1999 : We show here that the reduction of LPL activity in J774.2 macrophages observed in the presence of interleukin ( IL-1 ) and IL-11 was sensitive to herbimycin A, with the effect of LPS, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on LPL activity being sensitive to both herbimycin A and wortmannin
Uchida et al., Naunyn Schmiedebergs Arch Pharmacol 1999 : Previously we showed that tumor necrosis factor-alpha (TNF-alpha) inhibits lipoprotein lipase (LPL) activity and its gene expression, an early marker of adipocyte differentiation, in cultured brown adipocytes
Sartippour et al., Diabetes 2000 (Diabetes Mellitus, Type 2) : Besides LPL overproduction, macrophages of diabetic patients exhibited an increase in basal and LPL induced tumor necrosis factor (TNF)-alpha release
Coppack et al., Proc Nutr Soc 2001 (Obesity) : TNF-alpha and IL-6 inhibit lipoprotein lipase , and TNF-alpha additionally stimulates hormone-sensitive lipase and induces uncoupling protein expression
Yang et al., Exp Mol Med 2002 : TNF also suppressed the lipoprotein lipase (LPL) activity of 3T3-L1 adipocytes ... RA could not reverse the TNF- induced LPL suppression at RA levels causing near complete inhibition of the TNF induced NO production ... These results indicate that RAs attenuate iNOS expression reversibly in TNF stimulated 3T3-L1 adipocytes, and that the TNF induced LPL suppression is not the result of NO overproduction
Kota et al., J Biol Chem 2005 : Differential effects of lipoprotein lipase on tumor necrosis factor-alpha and interferon-gamma mediated gene expression in human endothelial cells ... We examined the role of LPL in modulating tumor necrosis factor-alpha (TNF-alpha)- and interferon-gamma (IFN-gamma) mediated inflammatory cytokine signal transduction pathways in human aortic endothelial cells ( HAECs )
Albalat et al., Gen Comp Endocrinol 2006 : On the other hand, TNFalpha did not greatly affect LPL activity using this in vitro model
Zechner et al., J Biol Chem 1991 : Human recombinant tumor necrosis factor , a potent inhibitor of LPL gene transcription, had no effect on adipocyte apoE mRNA levels
Saera-Vila et al., Comp Biochem Physiol B Biochem Mol Biol 2007 : The precise mechanism for the inhibition of LPL gene expression by TNFalpha remains to be established in fish, but analysis of the 5'-flanking region evidenced the conservation through vertebrate evolution of a functional OCT-1/NF-Y site that would mediate the TNFalpha effects on LPL expression
Yang et al., Int J Mol Med 2007 : Scopoletin also partially reversed tumor necrosis factor-alpha induced suppression of LPL activity
Kawasaki et al., Cytotechnology 2010 : LPL activity was suppressed by TNF-alpha ... In the presence of TNF-alpha , Met and Cys significantly increased the LPL activity, and Met also enhanced the LPL mRNA level
Saxena et al., Arteriosclerosis 1990 : Tumor necrosis factor induced release of endothelial cell lipoprotein lipase
Earl et al., J Biol Response Mod 1990 : Pertussis toxin also significantly reduced TNF induced inhibition of lipoprotein lipase activity in 3T3-L1 adipocytes and TNF blockade of 3T3-L1 preadipocyte differentiation
Butterwith et al., Comp Biochem Physiol A Comp Physiol 1989 : 3. Inhibition of lipoprotein lipase synthesis in similar experiments in mammals has been attributed to the effects of TNF-alpha and/or IL-1, but recombinant human TNF-alpha and IL-1 had no effect on lipoprotein lipase activity in chicken adipocytes
Porat et al., Lymphokine Res 1989 : In infected animals, the effect of TNF alpha on LPL of inhibiting anabolic processes and enhancing secretion of FFA by adipocytes, may be important in providing additional energy needed by the immune system to combat invasion
Fried et al., J Lipid Res 1989 : The effects of the cytokine cachectin/tumor necrosis factor (TNF) on human adipose tissue lipoprotein lipase (LPL) were studied
Feingold et al., J Clin Invest 1989 (Diabetes Mellitus, Experimental) : These results indicate that the TNF induced increase in circulating lipid levels can occur in the absence of a TNF induced inhibition of adipose tissue lipoprotein lipase activity
Grunfeld et al., J Lipid Res 1989 : It is unlikely that the limited effects of TNF on LPL in vivo can account for the rapid and sustained increase in serum triglycerides
Hülsmann et al., Mol Cell Biochem 1988 : Tumor Necrosis Factor (TNF) inhibits lipoprotein lipase activity in cultured myocytes and in the Langendorff rat heart after 3 h perfusion with TNF of glucocorticoid pretreated rats
Chajek-Shaul et al., Biochim Biophys Acta 1989 (Hypertriglyceridemia) : It is suggested that the increase in lipoprotein lipase activity of heart and diaphragm resulted from an indirect effect of TNF
Tsujimoto et al., J Biochem 1987 : We also found that the cytotoxic activity of TNF on A673 cells and its inhibitory effect on lipoprotein lipase were parallel with the cytotoxic activity on L929 cells, but the growth enhancing activity on FS-4 cells and the cytotoxic activity on endothelial cells were not
Silva et al., Braz J Med Biol Res 1988 (Hypertriglyceridemia...) : The hyperlipidemia that accompanies this infection may be mediated by the TNF inhibition of lipoprotein lipase activity
White et al., J Lipid Res 1988 (Arteriosclerosis) : Since LPS stimulates macrophage production of cachectin/tumor necrosis factor (TNF), a potent inhibitor of LPL production by the 3T3-L1 adipocyte-like cell line, it was determined whether TNF reduces macrophage LPL levels
Zechner et al., Mol Cell Biol 1988 : Recombinant human cachectin/tumor necrosis factor diminished both LPL activity and LPL mRNA levels ... The effect of recombinant human cachectin tumor necrosis factor on LPL mRNA levels was shown by nuclear run-on experiments to be exerted transcriptionally
Enerbäck et al., Gene 1988 : In the liver, TNF caused a marked increase in LPL mRNA levels, which are normally very low
Kern et al., J Lipid Res 1988 : Recombinant human tumor necrosis factor does not inhibit lipoprotein lipase in primary cultures of isolated human adipocytes ... Previous studies have demonstrated that cachectin/tumor necrosis factor (TNF) inhibits lipoprotein lipase (LPL) activity in cultures of 3T3-L1 cells ... To determine whether TNF also inhibits LPL in human adipocytes, primary cultures of isolated human adipocytes were exposed to a spectrum of concentrations of recombinant human TNF ... In contrast, the same TNF in the same concentrations progressively inhibited LPL activity and immunoreactive mass in 3T3-L1 cells
Sopher et al., Immunol Lett 1987 : Human recombinant TNF ( 1000 U/ml ) and murine recombinant IL-1 ( 100 U/ml ) did not affect LPL secretion or cell proliferation in the J774.1 cell line over a period of 72 and 24 h, respectively
Semb et al., J Biol Chem 1987 : Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo ... Thus, TNF suppresses lipoprotein lipase synthesis in adipocytes, but not in other tissues, and has some as yet undefined effect on lipoprotein lipase turnover in extrahepatic tissues, which results in increased transport of active lipase through plasma to the liver
Price et al., Arch Biochem Biophys 1986 : Regulation of lipoprotein lipase synthesis by recombinant tumor necrosis factor -- the primary regulatory role of the hormone in 3T3-L1 adipocytes
Price et al., Biochem J 1986 : Regulation of lipoprotein lipase synthesis in 3T3-L1 adipocytes by cachectin
Reiner et al., J Lipid Res 1994 (Second Messenger Systems) : Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation ... We have previously found that lipoprotein lipase (LPL) induces tumor necrosis factor alpha (TNF alpha) mRNA expression and TNF alpha protein production in the ANA-1 macrophage cell line and in resident murine macrophages ... The present study was designed to elucidate the intracellular signalling pathways involved in the LPL induced TNF alpha gene expression ... Treatment of macrophages with two protein kinase C ( PKC ) inhibitors, 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine hydrochloride ( H7 ) and calphostin C, suppressed LPL induced TNF alpha mRNA expression and protein production ... Overnight treatment of ANA-1 cells with 100 ng/ml 4 beta-phorbol 12 beta-myristate 13 alpha-acetate ( PMA ) caused the suppression of both PKC activity and LPL induced TNF alpha mRNA expression ... Overall these data demonstrate that LPL induces TNF alpha mRNA expression in a PKC dependent manner and that the PKC effect involves transcriptional events as well as posttranscriptional modifications
Renier et al., Arterioscler Thromb Vasc Biol 1995 : Lipoprotein lipase (LPL) induces macrophage tumor necrosis factor-alpha (TNF-alpha) gene expression and protein secretion
Sperber et al., Clin Diagn Lab Immunol 1995 : TSST-1 stimulation of LPL resulted in IL-2 and TNF production but no IL-4, IL-6, or gamma interferon
Morin et al., J Clin Invest 1995 : Regulation of LPL by TNF alpha occurs at the level of LPL gene transcription and posttranscriptionally ... To elucidate further the transcriptional mechanism of TNF alpha inhibition of LPL gene transcription, transfection analysis was used to locate the site ( s ) of the LPL promoter that imparts the TNF alpha response
Berg et al., Cytokine 1994 (Cachexia...) : Western blot analysis of cell extracts showed that TNF caused a greater decrease in LPL protein production than D-factor.2+ with TNF, may contribute to the manifestations of cachexia
Renier et al., J Lipid Res 1994 : In view of the suppressive effect of tumor necrosis factor alpha (TNF alpha) on lipoprotein lipase (LPL) and of the potential proatherogenic effects of these two macrophage secretory products, we have tested the possibility that LPL could modulate the production of TNF alpha ... An additive effect of interferon gamma (IFN gamma) was observed on LPL induced TNF alpha mRNA expression ... We further established that LPL induced the transcription of the TNF alpha gene in macrophages ... These results show that the TNF alpha gene induction in response to LPL involves both transcriptional activation and the enhancement of TNF alpha mRNA stability
Sakayama et al., Biochem J 1996 (Bone Neoplasms...) : The effect of recombinant human tumour necrosis factor-alpha (TNF-alpha) on synthesis, activity and secretion of lipoprotein lipase (LPL) was examined using a human osteosarcoma cell line, osteosarcoma Takase (OST)
Renier et al., J Lipid Res 1996 (Arteriosclerosis) : Oxidant stress also modulated the regulation of macrophage LPL production by tumor necrosis factor alpha (TNF alpha) ... While antioxidants accentuated the inhibition of LPL by TNF alpha, addition of H2O2 significantly attenuated TNF alpha induced LPL inhibition ... As LPL has been shown to induce macrophage TNF alpha release, the effect of reactive oxygen species on LPL induced TNF alpha production was also examined ... Simultaneous treatment of macrophages with LPL and H2O2 or pretreatment of macrophages with H2O2 prior to LPL stimulation decreased the LPL induced TNF alpha release by macrophages to the same extent
Uchida et al., Eur J Pharmacol 1997 : Nitric oxide mediates down regulation of lipoprotein lipase activity induced by tumor necrosis factor-alpha in brown adipocytes ... The present study examined whether the suppressive effect of TNF-alpha on lipoprotein lipase activity is mediated by production of NO in the brown adipocytes ... The suppressive effect of TNF-alpha on lipoprotein lipase activity was significantly prevented by NO synthase inhibitors, NG-nitro-L-arginine methyl ester ( L-NAME ) and aminoguanidine, but not by D-NAME, an inactive isomer ... These results suggest that TNF-alpha stimulates brown adipocytes to express inducible NO synthase, followed by production of NO, which in turn mediates the suppressive effect of TNF-alpha on lipoprotein lipase activity
Halle et al., Exerc Immunol Rev 1998 (Arteriosclerosis...) : TNF-alpha also reduces lipoprotein lipase activity in white adipocytes, stimulates hepatic lipolysis, and increases plasminogen activator inhibitor-1 content in adipocytes