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IL1A — STAT1

Text-mined interactions from Literome

Tian et al., J Immunol 2000 (Carcinoma, Hepatocellular) : Furthermore, IL-1beta attenuated IFN-alphabeta induced STAT1 binding and tyrosine phosphorylation without affecting the level of STAT1 protein
Shen et al., Biochem J 2000 : Furthermore, IL-1beta selectively down-regulated the IL-6 induced tyrosine phosphorylation of STAT1 without affecting the level of STAT1 or tyrosine phosphorylation of STAT3
De Caterina et al., Arterioscler Thromb Vasc Biol 2001 : Electrophoretic mobility shift assays and immunoblotting of nuclear extracts showed that IFN-gamma activated signal transducers and activators of transcription ( STAT ) -1alpha and interferon regulatory factor (IRF)-1 but not NF-kappaB, whereas LC IL-1alpha activated NF-kappaB but not STAT-1alpha or IRF-1
Weber et al., Am J Physiol Endocrinol Metab 2003 : Using overexpression and antisense depletion, we provide evidence that HSP70 does not mediate the inhibitory actions of PGJ ( 2 ) on IL-1 induced NF-kappaB or IFN-gamma induced STAT1 activation or cytokine stimulated iNOS expression by beta-cells
Nguyen et al., J Interferon Cytokine Res 2003 : Interleukin-1 (IL-1) induces the phosphorylation of Stat1 on serine 727 but not on tyrosine 701 ... Analyses of mutant I1A cells, which lack the IL-1 receptor associated kinase (IRAK), and of I1A cells reconstituted with deletion mutants of IRAK show that the IL-1 mediated phosphorylation of Stat1 on serine requires the IRAK protein but not its kinase activity and does not involve phosphatidylinositol-3'-kinase (PI3K) or the mitogen activated protein ( MAP ) kinases p38 or ERK ... IL-1 and tumor necrosis factor (TNF) enhance the serine phosphorylation of Stat1 that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma mediated, Stat1-driven gene expression, thus contributing to the synergistic activities of these proinflammatory cytokines