Nakao et al., Trends Mol Med 2002
(Inflammatory Bowel Diseases...) :
Recent reports have implicated Smad7 as a crucial regulator of TGF-beta activity in human disease ; aberrant expression of Smad7 is involved in inflammatory bowel disease and scleroderma
Monteleone et al., World J Gastroenterol 2012
(Colitis, Ulcerative...) :
In this article we review the available data supporting the pathogenic role of Smad7 in IBD and discuss whether and how Smad7 antisense therapy could help dampen the ongoing inflammation in IBD