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NFKBIA — SAA1
Text-mined interactions from Literome
Jijon et al., Eur J Immunol 2005
:
SAA induced
IkappaB-alpha degradation, RelA serine 536 ( S536 ) phosphorylation, NF-kappaB transcriptional activity, RelA recruitment to the IL-8 gene promoter and endogenous gene expression ( IL-8, COX-2 ) in HT-29 cells ... Finally,
SAA induced EGFP expression in intestinal explants isolated from kappaB-EGFP transgenic mice and
enhanced RelA and
IkappaBalpha phosphorylation in primary IEC
Mullan et al., Arthritis Rheum 2006
(Arthritis, Rheumatoid...) :
Furthermore,
A-SAA induced
IkappaBalpha degradation and NF-kappaB translocation, suggesting that its proinflammatory effects are mediated in part by NF-kappaB signaling
Okamoto et al., J Rheumatol 2008
(Arthritis, Rheumatoid) :
SAA induced
IkappaBalpha degradation, with the peak effect around 30 minutes ... Preincubation of SAA with soluble recombinant RAGE protein prevented
SAA induced
IkappaBalpha degradation