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PPP1R12A — RHOA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RHOA — PPP1R12A (colocalization, biochemical) Havugimana et al., Cell 2012
• MIPS CORUM MRIP-MBS-RHOA complex: MRIP-MBS-RHOA complex complex (MPRIP-PPP1R12A-RHOA) Surks et al., J Biol Chem 2003*
• IRef Hprd Interaction: PPP1R12A — RHOA (in vivo) Nakai et al., Blood 1997*
• IRef Hprd Interaction: PPP1R12A — RHOA (in vitro) Nakai et al., Blood 1997*
• IRef Intact Interaction: Complex of 13 proteins (association, anti bait coimmunoprecipitation) Koga et al., J Biol Chem 2005*
• IRef Ophid Interaction: PPP1R12A — RHOA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PPP1R12A — RHOA (aggregation, confirmational text mining) Nakai et al., Blood 1997*
• STRING interaction: RHOA — PPP1R12A (interaction, mapped from kegg_pathways)
• STRING interaction: RHOA — PPP1R12A (interaction, mapped from reactome)
• STRING interaction: PPP1R12A — RHOA (interaction, mapped from kegg_pathways)
• STRING interaction: PPP1R12A — RHOA (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Surks et al., J Biol Chem 2003 : M-RIP can assemble a complex containing both RhoA and MBS, suggesting that M-RIP may play a role in myosin phosphatase regulation by RhoA
Lartey et al., Biol Reprod 2006 : We tested the hypothesis that the uterine quiescence observed during gestation is mediated by an increase in RND protein expression inhibiting RHOA-ROCK mediated PPP1R12A phosphorylation
Riddick et al., J Cell Biochem 2008 : Because myosin phosphatase-rho interacting protein binds both RhoA and MLCP, we investigated whether myosin phosphatase-rho interacting protein was required for RhoA/ROCK mediated myosin phosphatase regulation
da Silva-Santos et al., Crit Care Med 2009 (Disease Models, Animal...) : Our findings revealed an impaired Rho-A/Rho-kinase mediated phosphorylation of MYPT1 in vessels from endotoxemic animals in a cyclic guanosine monophosphate dependent manner, suggesting that changes in mechanisms involved in calcium sensitization play a pivotal role in cardiovascular changes observed in septic shock
Ramachandran et al., Invest Ophthalmol Vis Sci 2011 : Consequent inhibition of RhoA activity reduces the phosphorylation of MYPT1 at Thr853, leading to a reduction in MLC phosphorylation and actomyosin contraction
Xu et al., Lab Invest 2012 (Liver Cirrhosis, Experimental) : Sal B decreased ET-1 induced RhoA and Rho associated coiled coil forming protein kinase ( ROCK) II activation by 66.84 % and by 76.79 %, respectively, and inhibited Thr ( 696 ) phosphorylation of MYPT1 by 80.09 %