◀ Back to RHOA

ARHGEF18 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RhoA activity: ARHGEF18 (ARHGEF18) → RHOA/GTP complex (RHOA) (modification, activates) Niu et al., Circ Res 2003*
  Evidence: assay
• NCI Pathway Database Regulation of RhoA activity: ARHGEF18 (ARHGEF18) → RHOA/GDP complex (RHOA) (modification, activates) Niu et al., Circ Res 2003*
  Evidence: assay
• NCI Pathway Database Regulation of RhoA activity: ARHGEF18 (ARHGEF18) → RHOA/GTP complex (RHOA) (modification, activates) Blomquist et al., Biochem J 2000*, Niu et al., Circ Res 2003*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RhoA activity: ARHGEF18 (ARHGEF18) → RHOA/GDP complex (RHOA) (modification, activates) Blomquist et al., Biochem J 2000*, Niu et al., Circ Res 2003*
  Evidence: assay, physical interaction
• Reactome Reaction: RHOA → ARHGEF18 (direct_complex)
• Reactome Reaction: RHOA → ARHGEF18 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RHOA — ARHGEF18 (direct interaction, pull down) Blomquist et al., Biochem J 2000*
• IRef Hprd Interaction: ARHGEF18 — RHOA (in vitro) Blomquist et al., Biochem J 2000*

Text-mined interactions from Literome

Niu et al., Circ Res 2003 : Using in vivo pull-down assays and dominant negative mutants of Rho GTPases, we have determined that p114RhoGEF activated RhoA and Rac1 but not Cdc42 proteins ... In summary, our data showed that the novel guanine nucleotide exchange factor p114RhoGEF regulates the activity of RhoA and Rac1, and that Gbetagamma subunits of heterotrimeric G proteins are activators of p114RhoGEF under physiological conditions
Tsuji et al., Mol Biol Cell 2010 (Neuroblastoma) : p114-RhoGEF and Lfc shRNAs also inhibited Dvl- and Wnt-3a induced RhoA activation, and p114-RhoGEF and Lfc proteins were capable of binding to Dvl and Daam1 ... Our results suggest that p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl induced RhoA activation and neurite retraction in N1E-115 cells
Terry et al., Nat Cell Biol 2011 : p114RhoGEF is required for RhoA activation at cell-cell junctions, and its depletion stimulates non-junctional Rho signalling and induction of myosin phosphorylation along the basal domain
Terry et al., PloS one 2012 : Accordingly, depletion of p114RhoGEF led to reduced RhoA , but increased Rac activity
Song et al., Tumour Biol 2013 (Adenocarcinoma...) : The Rho-specific guanine nucleotide exchanging factor p114RhoGEF is involved in RhoA activation and cell motility
Herder et al., Development 2013 : ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation ... We show that ArhGEF18 mediated activation of the small GTPase RhoA is required to maintain apicobasal polarity at the onset of retinal differentiation and to control the ratio of neurogenic to proliferative cell divisions