Nakao et al., Circ Res 2002
(Second Messenger Systems) :
Rho-kinase dependent phosphorylation of myosin phosphatase induced by SPC was inhibited by EPA, PP1, and Y27632
Thomas et al., Cardiovasc Res 2005
(Calcium Signaling) :
The Rho kinase inhibitor Y27632 reduced SPC induced vasoconstriction by approximately 70 % and abolished both SPC induced Ca2+ sensitisation in permeabilized IPA and the associated increase in MYPT1 phosphorylation ; Ca2+ sensitisation was substantially inhibited by GDPbetaS
Choi et al., Cardiovasc Res 2009
:
SPC induced a several-fold increase in Thr696 and Thr853 phosphorylation of MYPT1, but S1P did not affect phosphorylation of MYPT1