◀ Back to PLD5

EDN2 — PLD5

Text-mined interactions from Literome

Shome et al., Endocrinology 2000 : The activation of PLD in these cells by angiotensin II ( AngII ), endothelin-1 (ET-1), and platelet derived growth factor ( PDGF ) was found to be sensitive to inhibitors of the activation of ADP-ribosylation factor ( ARF ) but not to blockers of Rho protein function
Kester et al., J Cell Physiol 1992 : In addition, endothelin stimulated the release of 3H-choline and 3H-ethanolamine, demonstrating that additional phospholipids may serve as substrates for phospholipase D. Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced endothelin stimulated phospholipase D ... The calcium ionophore, ionomycin, did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished endothelin stimulated phospholipase D
van der Bend et al., Biochem J 1992 : Our results indicate that : ( 1 ) LPA is less efficient than endothelin in inducing phosphoinositide and PC breakdown ; ( 2 ) LPA induced PLD activation is short lived, levelling off after 2 min, whereas the endothelin stimulated increase in PLD activity persists for at least 1 h ; ( 3 ) the effect of LPA on PLD, like that of endothelin, is blocked by long-term pretreatment of the cells with phorbol ester, suggesting that PLD activation occurs through a protein kinase C-dependent mechanism
Sarri et al., J Neurochem 1995 : Histamine H1 and endothelin ETB receptors mediate phospholipase D stimulation in rat brain hippocampal slices ... Among the six neurotransmitter receptor agonists tested, only noradrenaline, histamine, endothelin-1 , and trans-ACPD stimulated phospholipase D in hippocampus and cortex, an effect that was strictly dependent of the presence of millimolar extracellular calcium concentrations
Ambar et al., Eur J Pharmacol 1993 (Glioma) : The activation of PLC or PLD by endothelin in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+
Dokhac et al., J Cardiovasc Pharmacol 1995 : In estrogen treated rat myometrium, endothelin-1 (ET-1) activated both the phospholipase C (PLC) which degrades PtdInsP2, resulting in an increased accumulation of inositol phosphates, and the phospholipase D pathway ( PLD ) as evidenced in the presence of butanol by an increased production of phosphatidylbutanol ( PBut )
Nord et al., Clin Exp Pharmacol Physiol 1996 : 4. Activation by endothelin of phosphatidylcholine-specific phospholipase D is under the dual regulation of protein kinase C and [Ca2+ ] i, with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary, modulatory role