◀ Back to MYD88
IRAK2 — MYD88
Pathways - manually collected, often from reviews:
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
MYD88
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
TOLLIP
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-alpha (IL1A)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
MYD88
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1RAcP (IL1RAP)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1RA (IL1RN)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, inhibits)
-
BioCarta signal transduction through il1r:
IL-1R (IL1R1)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
TRAF6
(modification, activates)
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
MYD88
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
TOLLIP
→
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
MYD88
→
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
IL-1RAcP (IL1RAP)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
IL-1-beta (IL1B)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
IL-1R (IL1R1)
(modification, collaborate)
-
KEGG Apoptosis:
IL1R1/IL1RAP
→
Complex of IRAK1-IRAK2-IRAK3-IRAK4-MYD88
(protein-protein, activation)
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
Reactome Reaction:
IRAK2
→
MYD88
(indirect_complex)
Uematsu et al., J Exp Med 2005, Rao et al., Mol Cell Biol 2005, Keating et al., J Biol Chem 2007, Gottipati et al., Cell Signal 2008, Kawagoe et al., Nat Immunol 2008, Wan et al., J Biol Chem 2009, Lin et al., Nature 2010, Flannery et al., J Biol Chem 2011
-
Reactome Reaction:
IRAK2
→
MYD88
(reaction)
Kollewe et al., J Biol Chem 2004, Uematsu et al., J Exp Med 2005, Rao et al., Mol Cell Biol 2005, Keating et al., J Biol Chem 2007, Gottipati et al., Cell Signal 2008, Kawagoe et al., Nat Immunol 2008, Wan et al., J Biol Chem 2009, Lin et al., Nature 2010, Flannery et al., J Biol Chem 2011
-
WikiPathways Regulation of toll-like receptor signaling pathway:
IRAK2
→
MYD88
(unknown)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
MYD88
→
IRAK2
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
MYD88
—
IRAK2
(coimmunoprecipitation)
Wesche et al., J Biol Chem 1999
-
IRef Biogrid Interaction:
IRAK2
—
MYD88
(physical association, affinity chromatography technology)
Zhou et al., Proc Natl Acad Sci U S A 2011*
-
IRef Biogrid Interaction:
IRAK2
—
MYD88
(physical association, affinity chromatography technology)
Wesche et al., J Biol Chem 1999
-
IRef Biogrid Interaction:
IRAK2
—
MYD88
(physical association, affinity chromatography technology)
Muzio et al., Science 1997
-
IRef Dip Interaction:
Complex of 13 proteins
(physical association, x-ray crystallography)
Lin et al., Nature 2010
-
IRef Dip Interaction:
IRAK2
—
MYD88
(physical association, pull down)
Lin et al., Nature 2010
-
IRef Hprd Interaction:
MYD88
—
IRAK2
(in vivo)
Boch et al., Biochem Biophys Res Commun 2003*, Muzio et al., Science 1997
-
IRef Hprd Interaction:
MYD88
—
IRAK2
(in vitro)
Boch et al., Biochem Biophys Res Commun 2003*, Muzio et al., Science 1997
-
IRef Intact Interaction:
IRAK2
—
MYD88
(physical association, anti tag coimmunoprecipitation)
Wesche et al., J Biol Chem 1999
-
IRef Ophid Interaction:
IRAK2
—
MYD88
(aggregation, confirmational text mining)
Muzio et al., Science 1997
-
IRef Ophid Interaction:
IRAK2
—
MYD88
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Janssens et al., Curr Biol 2002
:
The interaction of
MyD88 with IRAK
triggers IRAK phosphorylation, which is essential for its activation and downstream signaling ability
Burns et al., J Exp Med 2003
:
In the
presence of
MyD88s ,
IRAK-1 is not phosphorylated and neither activates NF-kappaB nor is ubiquitinated
Wesche et al., Immunity 1997
:
MyD88 binds to both IRAK ( IL-1 receptor associated kinase ) and the heterocomplex ( the signaling complex ) of the two receptor chains and thereby
mediates the association of
IRAK with the receptor