Gene interactions and pathways from curated databases and text-mining

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IRAK2 — MYD88

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Janssens et al., Curr Biol 2002 : The interaction of MyD88 with IRAK triggers IRAK phosphorylation, which is essential for its activation and downstream signaling ability
Burns et al., J Exp Med 2003 : In the presence of MyD88s , IRAK-1 is not phosphorylated and neither activates NF-kappaB nor is ubiquitinated
Wesche et al., Immunity 1997 : MyD88 binds to both IRAK ( IL-1 receptor associated kinase ) and the heterocomplex ( the signaling complex ) of the two receptor chains and thereby mediates the association of IRAK with the receptor