Gene interactions and pathways from curated databases and text-mining

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IRF6 — TP63

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Cowdery et al., J Immunol 1999 : While either LPS or CpG DNA induces p40 promoter activity, only CpG DNA induces an increase in p40 mRNA or protein secretion
Mason et al., Alcohol Clin Exp Res 2000 : Ethanol pretreatment suppressed LPS induced IL-12 p70 and p40 protein production in blood and lung
Liu et al., Immunology 2000 : Using the reverse transcription-polymerase chain reaction ( RT-PCR ), we found that CGRP also decreased the LPS induced IL-12 p40 mRNA levels
Samardzic et al., Clin Exp Immunol 2001 : The inhibitory effect of PTX was specific for IL-18, since LPS induced IL-12 p40 release was not suppressed either in splenocyte cultures or blood of LPS injected animals
Yang et al., Neuroendocrinology 2002 : LPS induced IL-12 p40 gene induction in the pituitary gland was suppressed after beta-adrenoceptor agonist pretreatment in vivo
Zhu et al., J Biol Chem 2003 : In this study, a composite NFAT/ICSBP binding site at -68 to -54 is identified that is functionally important for p40 promoter activation by lipopolysaccharide (LPS) and LPS plus IFN-gamma
Roy et al., J Allergy Clin Immunol 2003 (Asthma...) : Farm barn DNA significantly potentiated ( P < or =.05 ) LPS induced IL-10 and IL-12 p40 but not tumor necrosis factor-alpha release ( 13-fold, 3-fold, and 1.5-fold increases, respectively )
Yamada et al., Eur J Immunol 2004 : Because neither globular head of C1q (gC1q) nor collagen-like region of C1q ( cC1q ) failed to suppress LPS induced IL-12p40 production, both gC1q and cC1q, and/or some specialized conformation of native C1q may be required for the inhibition
Tada et al., Cytokine 2004 : Low dose LPS ( 1 ng/ml ) increased IL-6 and IL-12 p40 production by Mphi ... In contrast, only high dose LPS ( 1 microg/ml ) induced IL-6 but not IL-12 p40 production by LC
Matsumoto et al., J Immunol 2004 (Inflammation) : We report in this work that, unexpectedly, simvastatin enhances LPS induced IL-12p40 production by murine macrophages, and that it does so by activating the IL-12p40 promoter
Fronhofer et al., J Leukoc Biol 2006 : Antisense down-regulation of PKC-delta increased LPS stimulated IL-12p40 secretion and fully prevented the effects of FcgammaR ligation or PMA on IL-12p40 secretion ... In contrast, down-regulation of PKC-epsilon blocked LPS stimulated secretion of IL-12p40 ... Down-regulation of PKC-alpha had no effect on LPS stimulated IL-12p40 secretion ... The results suggest a negative role for PKC-delta and a positive role for PKC-epsilon in the regulation of LPS stimulated IL-12p40 secretion
Saito et al., Clinical and vaccine immunology : CVI 2006 : These results suggest that some negative regulatory mechanisms against LPS induced IL-12 p40 production are constitutively functioning in RAW264.7 cells but not in the other types of cells ... Pretreatment of the cells with phorbol myristate acetate to enhance ERK activation reduced p40 production in response to the optimal LPS stimulation
Tomczak et al., J Immunol 2006 (Colitis...) : Consistent with a defect in the suppressive effects of IL-10 in the absence of p50/p105, we found that the ability of IL-10 to control LPS induced expression of IL-12 p40 was significantly compromised in macrophages lacking p50/p105
Xu et al., J Immunol 2007 (Encephalomyelitis, Autoimmune, Experimental) : In primary astrocytes, LPS induced the production of IL-12p40 , IL-23, and IL-27p28 proteins
Wolf et al., J Neuroimmunol 2007 (Encephalomyelitis, Autoimmune, Experimental) : Spleen cells proliferated and secreted IFN-gamma in response to MBP ( 68-86 ), and secreted IL-6 and IL-12p40 in response to CpG-ODN and LPS
Usluoglu et al., Eur J Immunol 2007 : Knockdown of RIP2 by siRNA inhibited LPS dependent expression of IL-12 p40
Yamauchi et al., Int Immunol 2007 (Genetic Predisposition to Disease...) : Thus, we hypothesized that Ifi202 is involved in elevated IL-12 production from BWF1 BMDCs. Overexpression of Ifi202 enhanced the LPS induced IkappaB-zeta, IL-12p40 and NF-kappaB promoter activities, while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line, RAW 264.7
Lin et al., J Leukoc Biol 2007 : Treatment of PlGF-DC or classical-DC with PlGF resulted in the down-regulation of CD80, CD86, CD83, CD40, and HLA-DR expression, and CD1a was increased, as well as the inhibition of IL-12 p70, p40 , IL-8, and TNF-alpha production in response to LPS stimulation
Calippe et al., J Immunol 2008 : In striking contrast, we show that chronic administration of E2 to ovariectomized mice markedly increases the expression of IL-1beta, IL-6, IL-12p40 , and inducible NO synthase by resident peritoneal macrophages in response to LPS ex vivo
Wang et al., Sci China C Life Sci 2002 : Our findings indicated that thermal injury mediated the inhibition of AP-1 and NF-kappaB DNA binding activities and c-fos and IL-12 p40 gene expressions in response to LPS
Yamauchi et al., International journal of biological sciences 2009 : AZM reduced the induction of IL-12p40 by LPS/IFN-gamma in a dose dependent manner
Boucher et al., Viral Immunol 2010 (HIV Infections...) : Disparate regulation of LPS induced MAPK signaling and IL-12p40 expression between different myeloid cell types with and without HIV infection
Mokart et al., Acta Anaesthesiol Scand 2010 (Digestive System Neoplasms...) : After surgery, the septic patients showed drastic failure to up-regulate monocyte LPS stimulated production of IL-12 p40
Ko et al., Immune network 2010 : LPS induced IL-6 and IL-12p40 production in macrophages was suppressed when macrophages were treated with the GSKi peptide
Martins et al., J Leukoc Biol 2011 : Finally, splenic DCs of GR-1 injected mice produced less IL-12/23 p40 than those of PBS injected mice in response to LPS ex vivo, and this was at least partially dependent on exposure to GR-1 induced G-CSF in vivo
Das et al., J Biol Chem 2011 (Substance Withdrawal Syndrome) : This study investigated for the first time the role of glucocorticoids in MW modulation of LPS induced IL-12p40 , a key cytokine playing a pivotal role in immunoprotection ... ERK inhibitors reversed MW and MW plus corticosterone inhibition of LPS induced IL-12p40
Zhao et al., PloS one 2012 : Nfkb1 inhibits LPS induced IFN-ß and IL-12 p40 production in macrophages by distinct mechanisms
Hayes et al., Blood 1995 : LPS inducibility of p40 expression required only a brief exposure to IFN-gamma ( 2 hours ), while prolonged exposure ( +/- 24 hours ) to IFN-gamma resulted in diminishing levels of p40 mRNA
Ma et al., J Exp Med 1996 : We show here that IFN-gamma enhances IL-12 production mostly by priming phagocytic cells for lipopolysaccharide (LPS) induced transcription of the IL-12 p40 gene, which encodes the heavy chain of the IL-12 heterodimer ; furthermore, IFN-gamma directly induces transcription of the IL-12 p35 gene, which encodes the light chain of IL-12, and has at least an additive effect with LPS stimulation in inducing its transcription ... Because the RAW264.7 cell line is easily transfectable and regulates the endogenous IL-12 p40 gene in response to IFN-gamma or LPS similarly to human monocytes, it was used for analysis of the regulation of the cloned human IL-12 p40 promoter
Isler et al., Am J Respir Cell Mol Biol 1999 : LPS alone induced IL-12 p40 but not IL-12 p70 production in monocytes and in AM