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CCL2 — IL18

Text-mined interactions from Literome

Murao et al., FEBS Lett 1999 : In human vascular endothelial cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous monocyte chemoattractant protein-1 protein secretion, mRNA expression and promoter activity
Ishikawa et al., J Am Soc Nephrol 1999 : Bioflavonoid quercetin inhibits interleukin-1 induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB
Akoum et al., J Clin Endocrinol Metab 2000 (Endometriosis) : Estradiol amplifies interleukin-1 induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis ... In the present study we report that estradiol ( E2 ) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1 induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid ( mRNA ) synthesis, whereas progesterone had no significant effects
Momoi et al., Chest 2001 (Adenocarcinoma...) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induced endogenous MCP-1 protein secretion and messenger RNA expression
Hanifi-Moghaddam et al., Diabetes 2003 (Diabetes Mellitus, Type 1) : Of six mediators mainly produced by innate immunity cells, three were associated with multiple autoantibody status ( IL-18 increased , MIF and MCP-1 decreased ) and three were unaffected ( IL-12, MIP-1beta, IP-10 )
Elhofy et al., J Leukoc Biol 2005 (Encephalomyelitis, Autoimmune, Experimental) : Overexpression of CCL2 in the CNS resulted in decreased interleukin-12 receptor expression by antigen-specific T cells
Yoo et al., J Immunol 2005 : IL-18 induces monocyte chemotactic protein-1 production in macrophages through the phosphatidylinositol 3-kinase/Akt and MEK/ERK1/2 pathways ... However, it has been unclear whether IL-18 is involved in the induction of MCP-1 ... This investigation was initiated to determine whether IL-18 can induce MCP-1 production, and if so, by which signal transduction pathways ... We found that IL-18 induced the production of MCP-1 in macrophages, which was IL-12 independent and was not mediated by autocrine cytokines such as IFN-gamma or TNF-alpha ... We then examined signal transduction pathways involved in IL-18 induced MCP-1 production ... On the basis of these observations, we conclude that IL-18 induces MCP-1 production through the PI3K/Akt and MEK/ERK1/2 pathways in macrophages
Liang et al., Nephrology (Carlton) 2007 : Cell apoptosis, alpha-smooth muscle actin expression, type I collagen and fibronectin production as well as MCP-1 secretion were promoted by IL-18 in dosage- and/or time dependent manners, but RANTES secretion was not affected
Amin et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid) : IL-18 significantly enhanced the production of SDF-1alpha/CXCL12, MCP-1/CCL2 , and VEGF in RA ST fibroblasts, in a time- and concentration dependent manner ... Additionally, RA ST fibroblast IL-18 induced MCP-1/CCL2 production was mediated by JNK, PI3K, and NFkappaB
Cho et al., Exp Mol Med 2007 (Arthritis, Rheumatoid) : MCP-1 increased the proliferation of FLS and the production of IL-15, TNF-alpha, and IL-18
Pradeep et al., J Periodontol 2009 (Alveolar Bone Loss...) : A previous study showed the induction of MCP-1 by IL-18 in mice macrophages
Burel et al., Nucleic acid therapeutics 2013 : In mice, the alterations at 70 mg/kg/week included spleen weight increase up to 1.4-fold relative to control, increases in alanine aminotransferase and aspartate aminotransferase up to 1.8-fold over control, interleukin-10 increases up to 3.7-fold, and monocyte chemoattractant protein-1 increase up to 1.9-fold over control
Nussbaumer et al., J Immunol 2013 : We report in this article that downstream depletion of geranylgeranyl pyrophosphate ( GGPP ), which is required for protein prenylation, caused cell stress in monocytes, followed by caspase-1 mediated maturation and release of IL-18 , which, in turn, induced ?d T cell CCL2
Goppelt-Struebe et al., FEBS Lett 1995 : Synergistic induction of monocyte chemoattractant protein-1 ( MCP-1 ) by platelet derived growth factor and interleukin-1
Hayashi et al., J Neuroimmunol 1995 : Lipopolysaccharide (LPS), interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induced MCP-1 secretion by astrocytes, but not microglia
Colotta et al., Am J Pathol 1994 : Induction of MCP-1 transcript by thrombin was not reduced by blocking interleukin-1 and tumor necrosis factor, suggesting that these mediators are not involved in thrombin induced expression of MCP-1
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Puren et al., J Clin Invest 1998 : Mature IL-18 induced IL-8, macrophage inflammatory protein-1alpha, and monocyte chemotactic protein-1 in human peripheral blood mononuclear cells in the absence of any co-stimuli