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ICAM1 — PTEN
Text-mined interactions from Literome
Tsoyi et al., Atherosclerosis 2009
:
Upregulation of
PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively
inhibits lipopolysaccharide induced VCAM-1 but not
ICAM-1 expression in human endothelial cells
Tsoyi et al., Atherosclerosis 2010
:
PTEN differentially
regulates expressions of
ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3ß/GATA-6 signaling pathways in TNF-a activated human endothelial cells ...
PTEN strongly
inhibited VCAM-1 but not
ICAM-1 , however this inhibitory effect was reversed by co-transfection with constitutively active-Akt ( CA-Akt-HA ) in TNF-a stimulated ECs ... It is concluded that
PTEN selectively
inhibits expression of VCAM-1 but not
ICAM-1 through modulation of PI3K/Akt/GSK-3ß/GATA-6 signaling cascade in TNF-a treated ECs