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ICAM1 — INS

Text-mined interactions from Literome

Marfella et al., Circulation 2000 (Diabetes Mellitus, Type 2...) : We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 ( sICAM-1 ) and vascular adhesion molecule-1 ( sVCAM-1 ) in normal subjects and in patients with type 2 diabetes
Aljada et al., J Clin Endocrinol Metab 2000 : Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide ... Insulin ( 100 and 1000 microU/mL ) caused a decrease in the expression of ICAM-1 ( messenger ribonucleic acid and protein ) by these cells in a dose dependent manner after incubation for 2 days ... To examine whether the insulin induced inhibition of ICAM-1 was mediated by nitric oxide ( NO ) from increased endothelial NOS, HAEC were treated with N ( omega ) -nitro-L-arginine, a NOS inhibitor ... N ( omega ) -Nitro-L-arginine inhibited the insulin induced decrease in ICAM-1 expression in HAEC at the messenger ribonucleic acid and protein levels ... Thus, the inhibitory effect of insulin on ICAM-1 expression is mediated by NO ... We conclude that insulin reduces the expression of the proinflammatory adhesion molecule ICAM-1 through an increase in the expression of NOS and NO generation and that insulin may have a potential antiinflammatory and antiatherosclerotic effect rather than a proatherosclerotic effect
Aljada et al., Metabolism 2002 : We have recently demonstrated that insulin also inhibits the expression of intracellular adhesion molecule-1 ( ICAM-1 ) and monocyte chemoattractant protein-1 ( MCP-1 ), 2 major proinflammatory mediators, by human aortic endothelial cells ( HAEC ) and the proinflammatory mediator, nuclear factor ( NF-kappa B ), in the nucleus in parallel with an increase in endothelial nitric oxide synthase ( e-NOS ) expression
Li et al., Endocrinology 2009 : Insulin receptor small interfering RNA knockdown abolished insulin stimulated increases of ICAM-1 but not VCAM-1
Li et al., J Mol Cell Cardiol 2009 (Myocardial Reperfusion Injury) : These results demonstrate that insulin reduces endothelial P-selectin and ICAM-1 expression, and thus inhibits leukocyte-endothelium adherence in MI/R rabbit hearts