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EPO — IL1B
Text-mined interactions from Literome
Akimoto et al., J Hypertens 1999
:
The
effect of
erythropoietin on
interleukin-1beta mediated increase in nitric oxide synthesis in vascular smooth muscle cells ... Recently, we observed that recombinant human
erythropoietin ( rHuEPO )
inhibits the interleukin
(IL)-1beta induced nitric oxide ( NO ) production and inducible NO synthase (iNOS) expression in cultured rat vascular smooth muscle cells ( VSMC )
Imagawa et al., FASEB J 2003
(Anemia) :
However, 15 U/ml
IL-1beta , 220 U/ml TNF-alpha, or 10 ( -3 ) M L-NMMA
inhibited Epo protein production and promoter activity, respectively ... Addition of 10 microM K-7174 rescued these inhibitions of
Epo protein production and promoter activity
induced by
IL-1beta , TNF-alpha, or L-NMMA, respectively
Fandrey et al., Ann N Y Acad Sci 1991
(Carcinoma, Hepatocellular...) :
A dose dependent decrease of up to 60 % in
Epo production was
induced by
interleukin-1 beta , interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Krajewski et al., Cell Mol Life Sci 2007
(Anemia) :
We conclude that
IL-1beta , at least partially,
reduces hypoxia induced
EPO expression by down-regulation of HNF-4alpha
Fandrey et al., Eur J Biochem 1994
(Carcinoma, Hepatocellular...) :
Hypoxia induced
erythropoietin (Epo) production in vitro is
suppressed by
interleukin 1 beta (IL-1 beta) , tumor necrosis factor alpha (TNF) and phorbol esters
PiƩroni et al., Gerontology 1997
(Anemia...) :
These findings suggest that systemic TNF alpha or
IL-1 beta are not
involved in the
erythropoietin response to ACD