Gene interactions and pathways from curated databases and text-mining

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EPO — IL1B

Text-mined interactions from Literome

Akimoto et al., J Hypertens 1999 : The effect of erythropoietin on interleukin-1beta mediated increase in nitric oxide synthesis in vascular smooth muscle cells ... Recently, we observed that recombinant human erythropoietin ( rHuEPO ) inhibits the interleukin (IL)-1beta induced nitric oxide ( NO ) production and inducible NO synthase (iNOS) expression in cultured rat vascular smooth muscle cells ( VSMC )
Imagawa et al., FASEB J 2003 (Anemia) : However, 15 U/ml IL-1beta , 220 U/ml TNF-alpha, or 10 ( -3 ) M L-NMMA inhibited Epo protein production and promoter activity, respectively ... Addition of 10 microM K-7174 rescued these inhibitions of Epo protein production and promoter activity induced by IL-1beta , TNF-alpha, or L-NMMA, respectively
Fandrey et al., Ann N Y Acad Sci 1991 (Carcinoma, Hepatocellular...) : A dose dependent decrease of up to 60 % in Epo production was induced by interleukin-1 beta , interleukin-1 alpha, and tumor necrosis factor-alpha ( in that order of potency )
Krajewski et al., Cell Mol Life Sci 2007 (Anemia) : We conclude that IL-1beta , at least partially, reduces hypoxia induced EPO expression by down-regulation of HNF-4alpha
Fandrey et al., Eur J Biochem 1994 (Carcinoma, Hepatocellular...) : Hypoxia induced erythropoietin (Epo) production in vitro is suppressed by interleukin 1 beta (IL-1 beta) , tumor necrosis factor alpha (TNF) and phorbol esters
PiƩroni et al., Gerontology 1997 (Anemia...) : These findings suggest that systemic TNF alpha or IL-1 beta are not involved in the erythropoietin response to ACD