Gene interactions and pathways from curated databases and text-mining

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EGFR — SIRPA

Text-mined interactions from Literome

Wu et al., Oncogene 2000 (Brain Neoplasms...) : These data reveal a pathway that negatively regulates EGFR induced PI3-K activation in glioblastoma cells and involves interactions between SHP2 and tyrosine phosphorylated SIRPalpha1
Kapoor et al., Cancer Res 2004 (Glioblastoma) : Transcriptional regulation of signal regulatory protein alpha1 inhibitory receptors by epidermal growth factor receptor signaling ... Interestingly, pharmacological inhibition of the kinase activities of EGFR , erbB2, and src and activation of mitogen activated protein kinase, but not phosphatidylinositol 3'-kinase, significantly up-regulated SIRPalpha1 promoter activity