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E2F1 — NFYA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wang et al., Mol Endocrinol 1999
(Breast Neoplasms) :
Transcriptional activation of
E2F1 gene expression by 17beta-estradiol in MCF-7 cells is
regulated by
NF-Y-Sp1/estrogen receptor interactions ... Thus, transcriptional activation of
E2F1 gene expression in MCF-7 cells by E2 is
regulated by multiprotein
ER/Sp1-NF-Y interactions at GC-rich and two CCAAT elements in the proximal region of the E2F1 gene promoter
Matuoka et al., Ageing Res Rev 2002
:
In fact, the activities of NF-Y and
E2F decrease during ageing and a dominant negative
NF-YA induces SA-gal
Ru Lee et al., J Cell Biochem 2006
(Breast Neoplasms) :
Studies with inhibitors and dominant negative expression plasmids show that E2 activates cdc25A expression through activation of genomic ERalpha/Sp1 and
E2F1 and cAMP dependent
activation of
NF-YA
Gurtner et al., Cancer Res 2010
:
Transcription factor
NF-Y induces apoptosis in cells expressing wild-type p53 through
E2F1 upregulation and p53 activation