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CEBPA — E2F1

Pathways - manually collected, often from reviews:

• KEGG Pathways in cancer: CEBPA → E2F1/E2F2/E2F3 (gene expression, missing interaction)
• KEGG Pathways in cancer: CEBPA → E2F1/E2F2/E2F3 (gene expression, missing interaction)
• NCI Pathway Database E2F transcription factor network: CEBPA/BRM/RB1/E2F4 complex (CEBPA-SMARCA2-RB1-E2F4) → E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) (transcription, inhibits)
  Iakova et al., Cell 2003, Hiebert et al., Proc Natl Acad Sci U S A 1989
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes Rb-E2F complex: Rb-E2F complex complex (CEBPA-E2F1) Sahin et al., International journal of biological sciences 2010*
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
• IRef Innatedb Interaction: CEBPA — E2F1 (unknown, -) Kumagai et al., Int J Cancer 2009*

Text-mined interactions from Literome

Timchenko et al., Mol Cell Biol 1999 : The C/EBPalpha mediated regulation of E2F binding is specific, since the deletion of another C/EBP family member, C/EBPbeta, does not change the pattern of E2F binding during prenatal liver development ... Ectopic expression of C/EBPalpha in cultured cells also leads to a reduction of E2F complexes containing Rb family proteins
Timchenko et al., Nucleic Acids Res 1999 : E2F/p107 and E2F/p130 complexes are regulated by C/EBPalpha in 3T3-L1 adipocytes ... We have previously found that loss of C/EBPalpha in hepatocytes of newborn livers leads to increased proliferation, to a reduction in p21 protein levels and to an induction of S phase-specific E2F/p107 complexes ... In this paper, we investigated C/EBPalpha dependent regulation of E2F complexes in a well characterized cell line, 3T3-L1, and in stable transformants that conditionally express C/EBPalpha ... Our data suggest two pathways of C/EBPalpha dependent regulation of E2F/Rb family complexes : disruption of S phase-specific E2F/p107 complexes and induction of E2F/p130 complexes
Slomiany et al., Mol Cell Biol 2000 : Furthermore, C/EBPalpha can be shown to inhibit the S-phase induction of the E2F and DHFR promoters in permanent cell lines
Porse et al., Cell 2001 : E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo ... These results indicate that E2F repression by C/EBPalpha is critical for its ability to induce terminal differentiation, and thus provide genetic evidence that direct cell cycle control by a mammalian lineage-instructive transcription factor couples cellular growth arrest and differentiation
D'Alo' et al., Blood 2003 : Mutation of either results in loss of C/EBP alpha inhibition of E2F and down-regulation of c-Myc, but only mutation of the basic region results in loss of physical interaction with E2F
Loomis et al., Cancer Res 2007 : We observed that C/EBPalpha blocked Ras induced and epidermal growth factor induced E2F activity in keratinocytes and also blocked Ras induced cell transformation and cell cycle progression
Zaragoza et al., Mol Cell Biol 2010 : The data presented here show that, independently of pocket proteins, C/EBPalpha interacts with the dimerization partner ( DP ) of E2F and that C/EBPalpha-E2F/DP interaction prevents both binding of C/EBPalpha to its cognate sites on DNA and transactivation of C/EBP target genes