Gene interactions and pathways from curated databases and text-mining

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CDK2 — PDGFB

Text-mined interactions from Literome

Servant et al., J Cell Biol 2000 : However, while both factors increased the enzymatic activity of Cdk4, only PDGF-BB stimulated Cdk2 activity in late G ( 1 ) phase
Zhan et al., Arterioscler Thromb Vasc Biol 2002 : Ad-DN-c-Jun attenuated PDGF-BB induced downregulation of p27 ( Kip1 ), as shown by Western blot analysis, and the prevented PDGF-BB induced decrease in cyclin E/cyclin dependent kinase 2 complex associated p27 ( Kip1 ), as shown by immunoprecipitation study ... Furthermore, protein kinase assay showed that Ad-DN-c-Jun blocked PDGF-BB induced activation of cyclin dependent kinase 2
Nathe et al., Arterioscler Thromb Vasc Biol 2002 (Arteriosclerosis) : Consistent with this hypothesis is the finding that CDK2 activity, induced by PDGF-BB , is enhanced 2.3+/-0.2-fold in the presence of IL-1beta
Kundumani-Sridharan et al., Am J Pathol 2007 (Carotid Artery Injuries) : PDGF-BB induced cyclin D1 expression, CDK4 activity, and Rb protein phosphorylation, leading to VSMC growth and motility, and these responses were suppressed by the blockade of STAT-5B
Xu et al., Clin Exp Pharmacol Physiol 2011 : In addition, TSG significantly inhibited PDGF-BB induced phosphorylation of Rb and the expression of cyclin D1, CDK4, cyclin E, CDK2 and PCNA
Liu et al., Mol Cell Biochem 2011 : Berberine and DHEAS decreased the expression of CDK2 , CDK4, PCNA, cyclin D1, and cyclin E, which was induced by PDGF-BB
Rao et al., Biochim Biophys Acta 1999 (Hyperplasia...) : In contrast, PDGF-BB induced depletion of p27kip1 and increased cyclins D1 and E levels and CDK2 and CDK4 activities