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CDK2 — MYLIP
Text-mined interactions from Literome
Nakamachi et al., Arthritis Rheum 2009
(Arthritis, Rheumatoid...) :
Induction of
miR-124a in RA synoviocytes significantly
suppressed the production of the
CDK-2 and MCP-1 proteins
Agirre et al., Cancer Res 2009
(Disease Models, Animal...) :
Epigenetic down-regulation of
miR-124a induced an up-regulation of its target,
CDK6 , and phosphorylation of retinoblastoma ( Rb ) and contributed to the abnormal proliferation of ALL cells both in vitro and in vivo
Lu et al., Cancer Res 2011
(Nasopharyngeal Neoplasms) :
Mechanistic investigations revealed that
miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the
cyclin dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21 ( CIP1 ) in an EZH2 dependent manner
Maki et al., Anticancer Res 2012
(Mesothelioma...) :
miR-34b/c inhibited expression of cyclin-D1,
cyclin dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation
Giglio et al., J Cell Physiol 2013
:
In this report we describe that miR-24 directly targets p27 ( Kip1 ) and p16(Ink4a) in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that
miR-24 is
involved in
cyclin dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis