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ATR — CDK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database ATR signaling pathway: CDK2/Cyclin A complex (CDK2-CCNA2) → ATR/ATRIP complex (ATR-ATRIP) (modification, activates)
  Myers et al., Cancer Res 2007*
  Evidence: mutant phenotype, assay
• Reactome Reaction: CDK2 → ATR (reaction) Clarke et al., Biochem J 2005

Text-mined interactions from Literome

Shechter et al., Nat Cell Biol 2004 : DNA damage prevents origin firing through the ATM- and ATR dependent inhibition of Cdk2 and Cdc7 SPKs
Jazayeri et al., Nat Cell Biol 2006 : Moreover, we show that efficient ATM dependent ATR activation in response to DSBs is restricted to the S and G2 cell cycle phases and requires CDK kinase activity
Wilsker et al., Mol Cancer Ther 2012 (Colonic Neoplasms) : Upstream, the S-phase-specific cyclin dependent kinase (Cdk) 2 was required for robust activation of ATR in response to diverse chemotherapeutic agents ... While Cdk2 mediated ATR activation promoted cell survival after treatment with many drugs, signaling from ATR directly to the checkpoint kinase Chk1 was required for survival responses to only a subset of the drugs tested
Choi et al., Mol Cell 2013 (Genomic Instability...) : NEK8 Links the ATR Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies