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CD79A — TNFSF13
Text-mined interactions from Literome
Castigli et al., Proc Natl Acad Sci U S A 2004
:
APRIL by itself
induced IgA as well as IgG1 isotype switching in CD40-deficient IgM ( + ) IgD ( + ) sorted B cells
Castigli et al., Nat Genet 2005
(Common Variable Immunodeficiency...) :
B cells from individuals with TACI mutations expressed TACI but did not produce IgG and
IgA in
response to the TACI ligand
APRIL , probably reflecting impaired isotype switching
Castigli et al., J Allergy Clin Immunol 2006
(Common Variable Immunodeficiency...) :
B cells from individuals with TACI mutations did not produce IgG and
IgA in
response to the TACI ligand
a proliferation inducing ligand (APRIL) , probably reflecting impaired isotype switching
Sakurai et al., Blood 2007
:
Experiments using TACI siRNA into B cells indicated that TACI positively regulated
APRIL induced
IgA production in collaboration with heparan sulfate proteoglycans (HSPG)
Jin et al., Int J Mol Med 2008
(Common Variable Immunodeficiency...) :
B cells from individuals with TACI mutations do not produce IgG and
IgA in
response to the TACI ligand
a proliferation inducing ligand (APRIL) which probably suggests impaired isotype switching
Kanswal et al., J Immunol 2008
:
More importantly, TACI ligands BAFF or
APRIL were unable to
induce IgA/IgG/IgM secretion from newborn B lymphocytes
Kimberley et al., FASEB J 2009
:
In contrast to previous reports, we found that
APRIL alone is
sufficient to costimulate B-cell proliferation and drive
IgA production and does not require artificial antibody cross linking
Fabris et al., Ann N Y Acad Sci 2009
(Celiac Disease...) :
Because
APRIL promotes
IgA production, its overexpression may represent a physiological mechanism of compensation
Tezuka et al., Immunity 2011
:
IgA production was
dependent on
APRIL and BAFF production by pDCs