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CD40 — TNFSF11

Text-mined interactions from Literome

Hofbauer et al., J Cell Biochem 2002 : Conditioned medium harvested from IL-1beta treated XTC ( containing high concentrations of OPG ) inhibited RANKL induced CD40 upregulation and cluster formation of DC
Lee et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid) : CD40 ligation of RASFs also induced activation of ERK-1/2, p38 MAPK, and NF-kappaB and up-regulation of CD40 ligation induced RANKL expression, whereas osteoclastogenesis was reduced in RASFs transfected with a dominant negative mutant of IkappaB alpha or by an NF-kappaB inhibitor ... These results indicate that CD40 ligation of RASFs induces RANKL expression mainly via NF-kappaB activation and also results in enhanced osteoclast formation, both of which might play important roles in bone and cartilage destruction in RA