◀ Back to CASP3
CASP3 — PANX1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Pelegrin et al., J Biol Chem 2007
:
Inhibition of
pannexin-1 blocked
caspase-1 and IL-1beta processing and release in response to all three stimuli
Kanneganti et al., Immunity 2007
(Inflammation) :
Instead,
caspase-1 activation
required pannexin-1 , a hemichannel protein that interacts with the P2X(7) receptor
Sandilos et al., J Biol Chem 2012
:
Pannexin 1 (PANX1) channels mediate release of ATP, a `` find-me '' signal that recruits macrophages to apoptotic cells ; PANX1 activation during apoptosis requires
caspase mediated cleavage of
PANX1 at its C terminus, but how the C terminus inhibits basal channel activity is not understood