Gene interactions and pathways from curated databases and text-mining

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CASP3 — IFNA5

Text-mined interactions from Literome

Ludwiczek et al., Eur Cytokine Netw 2001 : Activation of caspase-3 by interferon alpha causes interleukin-16 secretion but fails to modulate activation induced cell death
Nakamura et al., J Hepatol 2007 (Carcinoma, Hepatocellular...) : Caspase-3 activation was exclusively increased by IFNalpha/5-FU combination treatment, which was compatible with enhancement of the synergistic apoptotic effect, and other caspases and apoptotic factors ( FLIP, BCL-xl, and Bax ) were also regulated by IFNalpha/5-FU