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BCL9 — MMP2
Text-mined interactions from Literome
Bae et al., Cancer Res 2006
(Adenocarcinoma...) :
Consistently,
Bcl-w , but not Bcl-2, overexpression
increased matrix metalloproteinase-2 (MMP-2) expression, and synthetic or natural inhibitors of MMP-2 abolished Bcl-w induced cell invasion ... Bcl-w overexpression also activated phosphoinositide 3-kinase (PI3K), Akt, and Sp1, and the blocking effects of each of these components using pharmacologic inhibitors, dominant negative mutants, or small interfering RNA abolished the ability of
Bcl-w to
induce MMP-2 and cell invasion
Lecoeur et al., Cell death & disease 2012
:
Pharmacologic inhibitors of the permeability transition pore, Bax/Bak inhibitors, and recombinant Bcl-2 and
Bcl-XL proteins do not
reduce Tat induced
MMP
Arbab et al., Evidence-based complementary and alternative medicine : eCAM 2012
:
We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2,
Bcl-xL , and Survivin ),
leading to disruption of mitochondrial
membrane potential ( MMP ) , cell membrane permeability, and release of cytochrome c from the mitochondria into the cytosol