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BCL9 — CTNNB1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: BCL9 (BCL9) → TCF4E/beta catenin complex (TCF7L2-CTNNB1) (modification, collaborate)
  Sampietro et al., Mol Cell 2006, Sustmann et al., Mol Cell Biol 2008, Brack et al., Dev Biol 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: BCL9 (BCL9) → TCF4E/beta catenin/BCL9 complex (TCF7L2-CTNNB1-BCL9) (modification, collaborate)
  Sampietro et al., Mol Cell 2006, Sustmann et al., Mol Cell Biol 2008, Brack et al., Dev Biol 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4E/beta catenin complex (TCF7L2-CTNNB1) → TCF4E/beta catenin/BCL9 complex (TCF7L2-CTNNB1-BCL9) (modification, collaborate)
  Sampietro et al., Mol Cell 2006, Sustmann et al., Mol Cell Biol 2008, Brack et al., Dev Biol 2009*
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: BCL9 → CTNNB1 (direct_complex) Kramps et al., Cell 2002, Thompson et al., Nat Cell Biol 2002, Belenkaya et al., Development 2002, Hoffmans et al., Development 2004, Hoffmans et al., Curr Biol 2005, Städeli et al., Mech Dev 2005, Sierra et al., Genes Dev 2006, Shilatifard et al., Annu Rev Biochem 2006, Sampietro et al., Mol Cell 2006, Schwab et al., BMC biology 2007, Song et al., Development 2007, Li et al., Genesis 2007, Sustmann et al., Mol Cell Biol 2008, Jessen et al., Bioessays 2008, Fiedler et al., Mol Cell 2008, Gu et al., J Cell Biol 2009, Kessler et al., Mech Dev 2009, Gu et al., Cell cycle (Georgetown, Tex.) 2012, Valenta et al., Genes Dev 2011, Valenta et al., EMBO J 2012, Willis et al., Blood 1998
• Reactome Reaction: BCL9 → CTNNB1 (reaction) Kramps et al., Cell 2002, Thompson et al., Nat Cell Biol 2002, Belenkaya et al., Development 2002, Hoffmans et al., Development 2004, Hoffmans et al., Curr Biol 2005, Städeli et al., Mech Dev 2005, Sierra et al., Genes Dev 2006, Sampietro et al., Mol Cell 2006, Schwab et al., BMC biology 2007, Song et al., Development 2007, Li et al., Genesis 2007, Sustmann et al., Mol Cell Biol 2008, Jessen et al., Bioessays 2008, Fiedler et al., Mol Cell 2008, Gu et al., J Cell Biol 2009, Kessler et al., Mech Dev 2009, Gu et al., Cell cycle (Georgetown, Tex.) 2012, Valenta et al., Genes Dev 2011, Valenta et al., EMBO J 2012, Willis et al., Blood 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: BCL9 — CTNNB1 (two hybrid) Hoffmans et al., Development 2004
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Mosimann et al., Cell 2006
• IRef Hprd Interaction: BCL9 — CTNNB1 (two hybrid) Hoffmans et al., Development 2004
• IRef Hprd Interaction: BCL9 — CTNNB1 (in vivo) Hoffmans et al., Development 2004
• IRef Innatedb Interaction: Complex of BCL9-CTNNB1 (unknown, -) Sampietro et al., Mol Cell 2006
• IRef Innatedb Interaction: BCL9 — CTNNB1 (unknown, -) Sampietro et al., Mol Cell 2006
• IRef Intact Interaction: Complex of CDC73-BCL9-CTNNB1 (association, anti bait coimmunoprecipitation) Mosimann et al., Cell 2006
• IRef Intact Interaction: BCL9 — CTNNB1 (physical association, two hybrid) Kramps et al., Cell 2002
• IRef Intact Interaction: BCL9 — CTNNB1 (physical association, pull down) Kramps et al., Cell 2002
• IRef Ophid Interaction: BCL9 — CTNNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sampietro et al., Mol Cell 2006 : We also demonstrate that beta-catenin Y142 phosphorylation, which has been proposed to regulate BCL9-2 binding, does not directly affect the interaction of beta-catenin with either BCL9 or BCL9-2
Xie et al., Crit Rev Immunol 2006 : Transcriptional coactivator beta-catenin recruited by TCF-1, and steroid receptor coactivators ( SRCs ) recruited by ROR gamma t, are also required for optimal stimulation of Bcl-xL expression
Lapham et al., Gene 2009 (Colorectal Neoplasms) : The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cells ... The activity of the Bcl-w promoter was increased or decreased, respectively, by overexpression of beta-catenin or dominant negative TCF4
Schenkel et al., J Immunol 2010 : Further, beta-catenin expression induced the antiapoptotic factor BcL-xL , suggesting that beta-catenin may mediate protection against activation induced cell death