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TP53 — WRN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: WRN — TP53 Yang et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: WRN — TP53 (coimmunoprecipitation) Yang et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: WRN — TP53 (experimental interaction detection) Yang et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: WRN — TP53 (affinity chromatography technology) Yang et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: WRN — TP53 (unspecified method) Yang et al., J Biol Chem 2002*
• IRef Biogrid Interaction: WRN — TP53 (physical association, affinity chromatography technology) Yang et al., J Biol Chem 2002*
• IRef Biogrid Interaction: WRN — TP53 (direct interaction, pull down) Brosh et al., J Biol Chem 2001*
• IRef Biogrid Interaction: WRN — TP53 (direct interaction, pull down) Yang et al., J Biol Chem 2002*
• IRef Hprd Interaction: TP53 — WRN (in vivo) Wang et al., J Biol Chem 2001*, Brosh et al., J Biol Chem 2001*, Yang et al., J Biol Chem 2002*, Sommers et al., Cancer Res 2005*
• IRef Hprd Interaction: TP53 — WRN (in vitro) Wang et al., J Biol Chem 2001*, Brosh et al., J Biol Chem 2001*, Yang et al., J Biol Chem 2002*, Sommers et al., Cancer Res 2005*
• IRef Intact Interaction: WRN — TP53 (direct interaction, far western blotting) Brosh et al., J Biol Chem 2001*
• IRef Intact Interaction: WRN — TP53 (colocalization, fluorescence microscopy) Brosh et al., J Biol Chem 2001*
• IRef Intact Interaction: WRN — TP53 (direct interaction, enzyme linked immunosorbent assay) Sommers et al., Cancer Res 2005*
• IRef Intact Interaction: Complex of 58 proteins (physical association, anti tag coimmunoprecipitation) Sowa et al., Cell 2009
• IRef Ophid Interaction: WRN — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., J Biol Chem 2001 (Bloom Syndrome) : We recently discovered that cells from Werner syndrome patients displayed a deficiency in p53 mediated apoptosis and WRN binds to p53
Brosh et al., J Biol Chem 2001 (Werner Syndrome) : In this study, we have demonstrated that p53 inhibits the exonuclease activity of the purified full-length recombinant WRN protein
Blander et al., J Biol Chem 2002 (Translocation, Genetic...) : WRN contributes to the induction of the p53 tumor suppressor protein by various DNA damaging agents
Sommers et al., Cancer Res 2005 (Werner Syndrome) : In vitro studies show that p53 inhibits RPA stimulated WRN helicase activity on an 849-bp M13 partial duplex substrate ... p53 effectively inhibited WRN helicase activity on model DNA substrate intermediates of replication/repair, a 5 ' ssDNA flap structure and a synthetic replication fork ... Regulation of WRN helicase activity by p53 is likely to play an important role in genomic integrity surveillance, a vital function in the prevention of tumor progression