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HIF1A — SOX9

Pathways - manually collected, often from reviews:

• FastForward regulation: HIF1A → SOX9 (transcriptional regulation, increase) Duval et al., Arthritis Rheum 2009*
  Evidence: REG, DNABINDING

Text-mined interactions from Literome

Robins et al., Bone 2005 : These findings suggest that hypoxia promotes the differentiation of mesenchymal cells along a chondrocyte pathway in part by activating Sox-9 via a HIF-1alpha dependent mechanism
Amarilio et al., Development 2007 : HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis ... Reduced expression of Sox9, a key regulator of chondrocyte differentiation, followed by reduction of Sox6, collagen type II and aggrecan in Hif1alpha depleted limbs raised the possibility that HIF1alpha regulation of Sox9 is necessary under hypoxic conditions for differentiation of prechondrogenic cells to chondrocytes