◀ Back to S100A8

S100A8 — S100A9

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: arachidonic acid/S100A8/S100A9 complex (S100A8-S100A9) (increases)
  Evidence: fatty acid binding was dependent on the calcium concentration;
• OpenBEL Selventa BEL large corpus: Complex of S100A8-S100A9 (increases, Translocation)
  Evidence: Upon elevation of the intracellular calcium level they are translocated from the cytosol to cytoskeleton and to plasma membrane (13).
• OpenBEL Selventa BEL large corpus: CYBA → Complex of S100A8-S100A9 (increases, S100A8/S100A9 Activity) Berthier et al., J Biol Chem 2003*
  Evidence: Moreover, MRP8/MRP14 initiated oxidase activation on its own, through a calcium-dependent specific interaction with cytochrome b558 as shown by atomic force microscopy and a structure-function relationship investigation.
• OpenBEL Selventa BEL large corpus: ICAM1 → Complex of S100A8-S100A9 (increases, S100A8/S100A9 Translocation) Ehlermann et al., Cardiovascular diabetology 2006*
  Evidence: Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.
• OpenBEL Selventa BEL large corpus: VCAM1 → Complex of S100A8-S100A9 (increases, S100A8/S100A9 Translocation) Ehlermann et al., Cardiovascular diabetology 2006*
  Evidence: Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.
• OpenBEL Selventa BEL large corpus: Complex of S100A8-S100A9 → PRKCA (increases, PRKCA Translocation, S100A8/S100A9 Activity)
  Evidence: Upon the activation of protein kinase C S100A8/A9 heterodimers are released from human monocytes by a novel secretion pathway that is energy-consuming and depends on an intact microtubule network
• NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) (modification, collaborate)
  Vogl et al., Nat Med 2007
  Evidence: assay
• NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
  Vogl et al., Nat Med 2007
  Evidence: assay
• NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
  Vogl et al., Nat Med 2007
  Evidence: assay
• NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) → MRP8/MRP14 complex (S100A8-S100A9) (modification, collaborate)
  Vogl et al., Nat Med 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) → TLR4/MD2 complex (LY96-TLR4) (modification, collaborate)
  Vogl et al., Nat Med 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14 complex (S100A8-S100A9) → TLR4/MD2 complex (LY96-TLR4) (modification, collaborate)
  Vogl et al., Nat Med 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → IRAK (IRAK1) (modification, activates) Vogl et al., Nat Med 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: S100A8 — S100A9
• IRef Bind_translation Interaction: S100A8 — S100A9 (x-ray crystallography)
• IRef Biogrid Interaction: S100A8 — S100A9 (direct interaction, two hybrid) Bandyopadhyay et al., Nat Methods 2010
• IRef Dip Interaction: S100A8 — S100A9 (genetic interference) Youssef et al., J Rheumatol 1999*
• IRef Hprd Interaction: S100A8 — S100A9 (two hybrid) Sopalla et al., Biol Chem 2002*
• IRef Hprd Interaction: S100A8 — S100A9 (in vitro) Sopalla et al., Biol Chem 2002*
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 13 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: S100A8 — S100A9 (physical association, two hybrid pooling approach) Bandyopadhyay et al., Nat Methods 2010
• IRef Intact Interaction: S100A8 — S100A9 (physical association, two hybrid) Pröpper et al., J Biol Chem 1999*
• IRef Mppi Interaction: S100A8 — S100A9 (two hybrid) Pröpper et al., J Biol Chem 1999*
• IRef Ophid Interaction: S100A8 — S100A9 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: S100A8 — S100A9 (aggregation, confirmational text mining) Eue et al., Int Immunol 2002*

Text-mined interactions from Literome

Bühling et al., Immunol Lett 2000 (Pneumonia) : TGF-beta1 led to a modulation of HLA-DR and MRP8/MRP14-antigen expression in vitro
Berthier et al., J Biol Chem 2003 : Changing the conformation state of cytochrome b558 initiates NADPH oxidase activation : MRP8/MRP14 regulation ... In a semi-recombinant cell-free assay, recombinant MRP8/MRP14 increased the affinity of p67phox for cytochrome b558 synergistically with p47phox ... In a semi-recombinant cell-free assay, recombinant MRP8/MRP14 increased the affinity of p67phox for cytochrome b558 synergistically with p47phox ... In a semi-recombinant cell-free assay, recombinant MRP8/MRP14 increased the affinity of p67phox for cytochrome b558 synergistically with p47phox
Tugizov et al., J Virol 2005 : We have shown that CKII activity and HPV16 E7 phosphorylation were inhibited by uptake of exogenous MRP-8/14 and activation of endogenous MRP-8/14
Viemann et al., Blood 2007 (Necrosis) : Furthermore, MRP8/MRP14 induced apoptotic caspase-9 and caspase-3 activation, DNA fragmentation, and membrane phosphatidylserine exposure in target cells
Zhou et al., Invest Ophthalmol Vis Sci 2009 (Pterygium) : Compared with tears from eyes without pterygium or other abnormalities, the level of S100 A8 increased 1.4- to 13.4-fold ( average fold change, 4.5 ) and S100 A9 increased 1.5- to 4.0-fold ( average fold change, 2.3 ) in 4 of 7 patients
Roth et al., Biochem Biophys Res Commun 1993 : TNF-alpha and IFN-g did not affect MRP8/MRP14 levels ... TNF-alpha and IFN-g did not affect MRP8/MRP14 levels