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ECT2 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RhoA activity: ECT2 (ECT2) → RHOA/GTP complex (RHOA) (modification, activates) Tatsumoto et al., J Cell Biol 1999*, Kimura et al., J Biol Chem 2000*
  Evidence: assay
• NCI Pathway Database Regulation of RhoA activity: ECT2 (ECT2) → RHOA/GDP complex (RHOA) (modification, activates) Tatsumoto et al., J Cell Biol 1999*, Kimura et al., J Biol Chem 2000*
  Evidence: assay
• Reactome Reaction: RHOA → ECT2 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Text-mined interactions from Literome

Saito et al., J Biol Chem 2004 (Cell Transformation, Neoplastic) : Among the known Rho GTPases expressed in NIH 3T3 cells, RhoA was predominantly activated by oncogenic ECT2 in vivo
Yüce et al., J Cell Biol 2005 : An ECT2-centralspindlin complex regulates the localization and function of RhoA ... Here, we dissect furrow formation in human cells and show that the RhoGEF ECT2 is required for cortical localization of RhoA and contractile ring assembly
Niiya et al., Oncogene 2006 : Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP bound RhoA
Keil et al., Cell cycle (Georgetown, Tex.) 2007 : Full activation of RhoA required Ect2 as well as p0071 indicating that these two proteins act in conjunction to regulate RhoA during cytokinesis
Kanada et al., Mol Biol Cell 2008 : Cytokinesis A is triggered by RhoA , which, in HeLa cells, is activated by the guanine nucleotide-exchange factor Ect2 localized at the central spindle and equatorial cortex ... Conversely, expression of dominant active Ect2 in interphase HT1080 cells enhanced RhoA activity and suppressed lamellipodia formation
Liot et al., PloS one 2011 : RhoA GDP/GTP cycling is required for normal cytokinesis and recent reports have shown that the exchange factor Ect2 and the GTPase activating protein MgcRacGAP regulate RhoA activity during mitosis
Su et al., Dev Cell 2011 : In animal cells, formation of the cytokinetic furrow requires activation of the GTPase RhoA by the guanine nucleotide exchange factor Ect2 ... How Ect2 , which is associated with the spindle midzone, controls RhoA activity at the equatorial cortex during anaphase is not understood ... Both guanine nucleotide exchange function and membrane targeting of Ect2 are essential for RhoA activation and cleavage furrow formation in human cells
Cook et al., Genes & cancer 2011 : Finally, although Ect2 dependent activation of RhoA has been implicated in cytokinesis, Ect2 can also activate Rac1 and Cdc42 to cause growth transformation
Tse et al., Mol Biol Cell 2012 : During cytokinesis, RhoA is activated by the RhoGEF ECT-2