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ARHGEF12 — RHOA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RHOA → Complex of ARHGEF12-PLXNB1 (directlyIncreases, ARHGEF12/PLXNB1 Activity)
  Swiercz et al., J Cell Biol 2004
  Evidence: Plexin-B1 has recently been shown to mediate activation of RhoA through a stable interaction with the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG.
• KEGG Vascular smooth muscle contraction: ARHGEF1/ARHGEF11/ARHGEF12 → RHOA (protein-protein, activation)
• KEGG Axon guidance: ARHGEF12 → RHOA (protein-protein, activation)
• KEGG Regulation of actin cytoskeleton: ARHGEF1/ARHGEF12 → RHOA (protein-protein, activation)
• KEGG Tuberculosis: CD209/CLEC4M → Complex of ARHGEF12-RHOA (protein-protein, binding/association)
• NCI Pathway Database Regulation of RhoA activity: ARHGEF12 (ARHGEF12) → RHOA/GTP complex (RHOA) (modification, activates) Fukuhara et al., FEBS Lett 2000*, Perrot et al., J Biol Chem 2002*, Aurandt et al., Proc Natl Acad Sci U S A 2002, Dubash et al., J Cell Sci 2007*
  Evidence: assay
• NCI Pathway Database Regulation of RhoA activity: ARHGEF12 (ARHGEF12) → RHOA/GDP complex (RHOA) (modification, activates) Fukuhara et al., FEBS Lett 2000*, Perrot et al., J Biol Chem 2002*, Aurandt et al., Proc Natl Acad Sci U S A 2002, Dubash et al., J Cell Sci 2007*
  Evidence: assay
• Reactome Reaction: RHOA → ARHGEF12 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Hirotani et al., Biochem Biophys Res Commun 2002, Oinuma et al., J Biol Chem 2003, Swiercz et al., J Cell Biol 2004, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RHOA — ARHGEF12 Kristelly et al., J Biol Chem 2004*
• IRef Bind_translation Interaction: RHOA — ARHGEF12 (x-ray crystallography) Kristelly et al., J Biol Chem 2004*
• IRef Biogrid Interaction: RHOA — ARHGEF12 (direct interaction, pull down) Reuther et al., J Biol Chem 2001*
• IRef Biogrid Interaction: RHOA — ARHGEF12 (physical association, affinity chromatography technology) Yang et al., PloS one 2013*
• IRef Biogrid Interaction: RHOA — ARHGEF12 (direct interaction, pull down) Suzuki et al., Proc Natl Acad Sci U S A 2003*
• IRef Hprd Interaction: RHOA — ARHGEF12 (in vitro) Reuther et al., J Biol Chem 2001*
• IRef Hprd Interaction: RHOA — ARHGEF12 (in vivo) Reuther et al., J Biol Chem 2001*
• IRef Intact Interaction: RHOA — ARHGEF12 (direct interaction, x-ray crystallography) Haupt et al., J Mol Biol 2004*
• IRef Intact Interaction: RHOA — ARHGEF12 (physical association, anti tag coimmunoprecipitation) Dong et al., EMBO J 2010*
• IRef Ophid Interaction: RHOA — ARHGEF12 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ying et al., Arterioscler Thromb Vasc Biol 2009 (Calcium Signaling) : Results showed that overexpression of PDZ-RhoGEF, but not p115-RhoGEF or leukemia associated RhoGEF (LARG) , enhanced RhoA activation by angiotensin II
Gasmi-Seabrook et al., J Biol Chem 2010 : Interestingly, this mutation does not affect RhoA activation by leukemia associated RhoGEF (LARG) , indicating that the PH domains of these two homologous GEFs may play different roles