◀ Back to RAC1
RAC1 — VAV2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
RAC1
→
VAV2
(directlyIncreases, VAV2 Activity)
Evidence: Cytoplasmic p120-catenin (p120) activates the RHO-family GTPases RAC1 and CDC42 (probably through the RHO guanine-nucleotide exchange factor (RHO-GEF) VAV2)
-
OpenBEL Selventa BEL large corpus:
RAC1
→
VAV2
(directlyIncreases, VAV2 Activity, RAC1 Activity)
Evidence: Vav2 phosphorylation observed in these experiments reflects the activation of Rac-specific Vav2 nucleotide exchange activity (Aghazadeh et al., 2000).
-
KEGG Focal adhesion:
VAV1/VAV2/VAV3
→
RAC1/RAC2/RAC3
(protein-protein, activation)
-
KEGG Natural killer cell mediated cytotoxicity:
VAV1/VAV2/VAV3
→
RAC1/RAC2/RAC3
(protein-protein, activation)
-
KEGG B cell receptor signaling pathway:
VAV1/VAV2/VAV3
→
RAC1/RAC2/RAC3
(protein-protein, activation)
-
KEGG Fc epsilon RI signaling pathway:
VAV1/VAV2/VAV3
→
RAC1/RAC2/RAC3
(protein-protein, activation)
-
KEGG Fc gamma R-mediated phagocytosis:
VAV1/VAV2/VAV3
→
RAC1/RAC2
(protein-protein, activation)
-
KEGG Leukocyte transendothelial migration:
VAV1/VAV2/VAV3
→
RAC1
(protein-protein, activation)
-
KEGG Regulation of actin cytoskeleton:
TIAM1/TIAM2/VAV1/VAV2/VAV3
→
RAC1/RAC2/RAC3
(protein-protein, activation)
-
KEGG Chemokine signaling pathway:
VAV1/VAV2/VAV3
→
RAC1/RAC2
(protein-protein, activation)
-
NCI Pathway Database Regulation of RAC1 activity:
VAV2 (VAV2)
→
RAC1/GDP complex (RAC1)
(modification, activates)
Abe et al., J Biol Chem 2000, Liu et al., Mol Cell Biol 2000*, Kawakatsu et al., J Biol Chem 2005*, Aoki et al., Mol Biol Cell 2005*
Evidence: assay
-
NCI Pathway Database Regulation of RAC1 activity:
VAV2 (VAV2)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Abe et al., J Biol Chem 2000, Liu et al., Mol Cell Biol 2000*, Kawakatsu et al., J Biol Chem 2005*, Aoki et al., Mol Biol Cell 2005*
Evidence: assay
-
NCI Pathway Database ErbB1 downstream signaling:
VAV2 (VAV2)
→
RAC1/GDP complex (RAC1)
(modification, activates)
Tamás et al., J Biol Chem 2003*, Kurokawa et al., Mol Biol Cell 2004
Evidence: assay
-
NCI Pathway Database ErbB1 downstream signaling:
VAV2 (VAV2)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Tamás et al., J Biol Chem 2003*, Kurokawa et al., Mol Biol Cell 2004
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
VAV2 (VAV2)
→
RAC1/GDP complex (RAC1)
(modification, activates)
Chiariello et al., Nat Cell Biol 2001, Ouyang et al., Proc Natl Acad Sci U S A 2008
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
VAV2 (VAV2)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Chiariello et al., Nat Cell Biol 2001, Ouyang et al., Proc Natl Acad Sci U S A 2008
Evidence: assay
-
NCI Pathway Database CDC42 signaling events:
VAV2 (VAV2)
→
RAC1/GDP complex (RAC1)
(modification, activates)
Kawakatsu et al., J Biol Chem 2005*
Evidence: assay
-
NCI Pathway Database CDC42 signaling events:
VAV2 (VAV2)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Kawakatsu et al., J Biol Chem 2005*
Evidence: assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
VAV2 (VAV2)
→
RAC1/GDP complex (RAC1)
(modification, activates)
Nakagawa et al., J Cell Sci 2001, Noren et al., J Biol Chem 2001, Kovacs et al., J Biol Chem 2002, Palacios et al., Nat Cell Biol 2002, Fukuyama et al., Oncogene 2006
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database PDGFR-beta signaling pathway:
VAV2 (VAV2)
→
RAC1/GDP complex (RAC1)
(modification, activates)
Takahashi et al., Genes Cells 2008, Miyata et al., J Biol Chem 2009
Evidence: mutant phenotype, other species
-
NCI Pathway Database PDGFR-beta signaling pathway:
VAV2 (VAV2)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Takahashi et al., Genes Cells 2008, Miyata et al., J Biol Chem 2009
Evidence: mutant phenotype, other species
-
NCI Pathway Database Nectin adhesion pathway:
VAV2 (VAV2)
→
RAC1/GDP complex (RAC1)
(modification, activates)
Kawakatsu et al., J Biol Chem 2005*, Sato et al., Cancer Sci 2005*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Nectin adhesion pathway:
VAV2 (VAV2)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Kawakatsu et al., J Biol Chem 2005*, Sato et al., Cancer Sci 2005*
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA2 forward signaling:
RAC1/GDP complex (RAC1)
→
Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3)
(modification, collaborate)
Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
Evidence: mutant phenotype, assay
-
Reactome Reaction:
VAV2
→
RAC1
(indirect_complex)
Tybulewicz et al., Immunol Rev 2003, Marston et al., Nat Cell Biol 2003, Bos et al., Cell 2007, Garrett et al., Exp Cell Res 2007
-
Reactome Reaction:
VAV2
→
RAC1
(reaction)
Abe et al., J Biol Chem 2000, Schmid et al., J Neurosci 2000, Zeng et al., Mol Cell Biol 2000, Chong et al., J Biol Chem 2001, Harrington et al., J Neurosci 2002, Parrini et al., Mol Cell 2002, Tybulewicz et al., Immunol Rev 2003, Marston et al., Nat Cell Biol 2003, Schmid et al., Neuroreport 2004*, Hall et al., Immunity 2006, Bos et al., Cell 2007, Garrett et al., Exp Cell Res 2007
-
WikiPathways Hepatitis C and Hepatocellular Carcinoma:
VAV2
→
RAC1
(activation)
-
WikiPathways Microglia Pathogen Phagocytosis Pathway:
PLCG2/LAT/VAV1/VAV2/VAV3
→
RAC1/RAC2/RAC3
(activation)
-
WikiPathways Chemokine signaling pathway:
VAV1/VAV2/VAV3
→
RAC1/RAC2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Abe et al., J Biol Chem 2000
:
Vav2 is an
activator of Cdc42,
Rac1 , and RhoA
Liu et al., Mol Cell Biol 2000
:
Vav2 activates
Rac1 , Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins ... Expression of a carboxy-terminal fragment of Vav2 decreased the elevation of Rac1 activity induced by epidermal growth factor, consistent with
Vav2 mediating
activation of
Rac1 downstream from growth factor receptors
Marignani et al., J Cell Biol 2001
:
Vav2 nucleotide exchange is Src dependent in vivo, since the coexpression of
Vav2 and dominant negative Src, or treatment with the Src inhibitor PP2,
blocks both Vav2 dependent
Rac activation and lamellipodia formation
Servitja et al., J Biol Chem 2003
(Cell Transformation, Neoplastic) :
Evidence of a
role for Tiam1 and
Vav2 in
Rac activation by Src
Marcoux et al., Oncogene 2003
:
EGF receptor
mediates adhesion dependent activation of the
Rac GTPase : a role for phosphatidylinositol 3-kinase and
Vav2
Miller et al., Mol Endocrinol 2005
(Breast Neoplasms) :
Activation of guanosine triphosphatase
Rac-1 in Chinese hamster ovary transfectants
required both Nek3 and
Vav2 and was inhibited by the overexpression of a kinase inactivating Nek3 mutant
Aoki et al., Mol Biol Cell 2005
:
Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits
Vav2 and Vav3 to
activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor stimulated PC12 cells ... Depletion of
Vav2 and Vav3 by RNA interference significantly
inhibited both
Rac1/Cdc42 activation and the formation of short processes leading to neurite outgrowth ... At the NGF induced protrusions, local phosphatidylinositol 3,4,5-trisphosphate accumulation recruited Vav2 and Vav3 to activate
Rac1 and Cdc42, and conversely,
Vav2 and Vav3 were
required for the local activation of PI3-kinase
Hunter et al., Mol Cell Biol 2006
:
Overexpression of either
Vav2 or Vav3 in primary microvascular endothelial cells
promotes Rac1 activation, cell migration, and assembly in response to ephrin-A1 stimulation ... Conversely, loss of
Vav2 and Vav3 GEFs
inhibits Rac1 activation and ephrin-A1 induced angiogenic responses both in vitro and in vivo
Murata et al., J Neurosci 2006
:
These results indicate that CD47 promotes development of dendrites and axons in hippocampal neurons in a manner dependent, at least in part, on activation of Cdc42 and
Rac mediated by Src as well as by FRG and
Vav2
Birukova et al., Exp Cell Res 2007
(Respiratory Distress Syndrome, Adult) :
Both PGs caused cAMP mediated activation of PKA-, Epac/Rap1- and
Tiam1/Vav2 dependent pathways of
Rac1 activation and EC barrier regulation
Garrett et al., Exp Cell Res 2007
:
VEGF induced
Rac1 activation in endothelial cells is
regulated by the guanine nucleotide exchange factor
Vav2
Yi et al., Cell Physiol Biochem 2007
:
Mechanism of homocysteine induced
Rac1/NADPH oxidase
activation in mesangial cells : role of guanine nucleotide exchange factor
Vav2 ... This
Vav2-siRNA also
blocked Rac activation induced by C16-Ceramide ( C16-Cer ), an intermediate lipid product stimulated by Hcys ... These results suggest that
Vav2 importantly
contributes to Hcys induced increase in
Rac1 activity and consequent activation of NADPH oxidase in RMCs via ceramide associated tyrosine phosphorylation
Lai et al., Oral Oncol 2008
(Carcinoma, Squamous Cell...) :
Transfection of activated
Vav2 into the immortalized keratinocyte cell line HaCat and a low-level expressing Vav2 invasive OSCC cell line
resulted in increased GTP bound
Rac1 and Cdc42 and increased invasion
Yi et al., Hypertension 2009
(Disease Models, Animal...) :
In the rat kidneys with transfection of a dominant-active Vav2 variant ( onco-Vav2 ), we found that overexpression of
Vav2 led to significant increases in
Rac1 activity, superoxide production, and glomerular injury, which was similar to that induced by hyperhomocysteinemia
Duan et al., J Biol Chem 2010
:
Inducible expression of a constitutively active form of
Vav2 , a Rho GTPase guanine nucleotide exchange factor activated by receptor tyrosine kinases, in three-dimensional MEC culture
activated Rac1 and Cdc42 ; Vav2 induction from early stages of culture impaired acinar morphogenesis, and induction in preformed acini disrupted the pre established acinar architecture and led to cellular outgrowths
Duan et al., J Biol Chem 2011
:
Overexpression of constitutively active
Vav2 activated
Rac1/Cdc42 and reorganized junctional actin cytoskeleton ; these effects were suppressed by WT Cbl and enhanced by a ubiquitin ligase-deficient Cbl mutant
Maruvada et al., Infect Immun 2012
(Escherichia coli Infections...) :
We further showed that the guanine nucleotide exchange factor
Vav2 , not ß-Pix, was
involved in E. coli K1-mediated
Rac1 activation
Valls et al., J Cell Sci 2012
:
Upon Wnt stimulation,
Rac1 activation
requires Rac1 and
Vav2 binding to p120-catenin