Gene interactions and pathways from curated databases and text-mining

◀ Back to RAC1

CTNNB1 — RAC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Fukata et al., J Biol Chem 1999 : Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin ... These results indicate that Cdc42 and Rac1 negatively regulate the IQGAP1 function by inhibiting the interaction of IQGAP1 with beta-catenin , leading to stabilization of the cadherin-catenin complex
Fukata et al., Mol Cell Biol 2001 : We have previously proposed that IQGAP1, an effector of Rac1 and Cdc42, negatively regulates cadherin mediated cell-cell adhesion by interacting with beta-catenin and by causing the dissociation of alpha-catenin from cadherin-beta-catenin-alpha-catenin complexes and that activated Rac1 and Cdc42 positively regulate cadherin mediated cell-cell adhesion by inhibiting the interaction of IQGAP1 with beta-catenin
Noritake et al., Mol Biol Cell 2004 : The small guanosine triphosphatase Rac1 is activated by E-cadherin mediated cell-cell adhesion and is required for the accumulation of actin filaments, E-cadherin, and beta-catenin at sites of cell-cell contact ... Together, these results indicate that Rac1 enhances the accumulation of actin filaments, E-cadherin, and beta-catenin by acting on IQGAP1 and suggest that there exists a positive feedback loop comprised of "E-cadherin mediated cell-cell adhesion -- > Rac1 activation -- > actin-meshwork formation by IQGAP1 -- > increasing E-cadherin mediated cell-cell adhesion. ''
Esufali et al., Oncogene 2004 : Expression of a constitutively active ( V12 ) Rac1 mutant caused up to 40-fold induction from the TOPFLASH promoter, and this was dependent on the presence of stabilized beta-catenin ... Furthermore, we show that Cyclin D1, an important biological Wnt target gene, is regulated by Rac1 in a beta-catenin/TCF dependent manner
Lyu et al., J Biol Chem 2005 : Wnt-7a induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and Rac synergistically induced the transcription of MMP-12
Ray et al., Cell Motil Cytoskeleton 2007 : The expression of constitutively active Rac1 ( CA-Rac1 ) restored beta-catenin to the cell periphery and prevented the formation of actin cortex and caused the appearance of F-actin stress fibers in polyamine depleted cells
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2007 : Paxillin-beta-catenin interactions are involved in Rac/Cdc42 mediated endothelial barrier-protective response to oxidized phospholipids
Wu et al., Cell 2008 : Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling ... Here we demonstrate that nuclear accumulation of beta-catenin in response to Wnt requires Rac1 activation
Upadhyay et al., Oncogene 2008 : Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling