UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

IL18 — PTEN

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: PTEN → IL18 (increases) Chandrasekar et al., Biochem Biophys Res Commun 2006 *
Evidence: In contrast, a significant but delayed increase in PTEN levels was observed following IL-18 treatment. The low basal level of PTEN showed no change for up to 3 h following IL-18 treatment, but increased at 6 and 12 h (Fig. 2A).

Text-mined interactions from Literome

Chandrasekar et al., Biochem Biophys Res Commun 2006 : Our results demonstrate that IL-18 reduced phospho-Akt and bcl-2 levels, stimulated NF-kappaB activation, and induced PTEN-promoter-reporter activity, mRNA expression, and protein levels in HCMEC ... IL-18 mediated PTEN transcription was enhanced by ectopic expression of wild type p65, but inhibited by dominant negative ( dn ) IkappaB-alpha, dnp65, and dnIKKbeta ... IL-18 induced activation of NF-kappaB and PTEN upregulation were mediated by p38MAPK
Zabalgoitia et al., Free Radic Biol Med 2008 : Overexpression of HO-1, treatment with HO-1 inducer hemin, or the CO donor cobalt ( III ) protoporphyrin IX all reversed IL-18 mediated NF-kappaB activation, PTEN induction, Akt suppression, and EC death ... HO-1 overexpression, HO-1 induction, or treatment with heme metabolites all reverse IL-18 mediated p38alpha MAPK and NF-kappaB activation, PTEN induction , Akt suppression, and EC death
Zhou et al., Int J Biochem Cell Biol 2013 : Besides, IL-18 increased level of PTEN phosphorylation to protect NHEM from damage induced by H ( 2 ) O ( 2 )