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PPARD — PPARGC1A

Text-mined interactions from Literome

Schuler et al., Cell Metab 2006 (Diabetes Mellitus, Type 2...) : PGC1alpha expression is controlled in skeletal muscles by PPARbeta , whose ablation results in fiber-type switching, obesity, and type 2 diabetes ... We also show that PPARbeta stimulates in myocytes the expression of PGC1alpha , a coactivator of various transcription factors, known to play an important role in slow muscle fiber formation
Hondares et al., Biochem Biophys Res Commun 2007 : PPARdelta , but not PPARalpha, activates PGC-1alpha gene transcription in muscle ... PPARdelta induces PGC-1alpha gene transcription through a PPAR-response element in the PGC-1alpha promoter ... A further positive autoregulatory loop of control relies on the induction of PPARdelta expression by PGC-1alpha
Bartke et al., Hormones (Athens) 2008 : Results obtained to date suggest that reduced Akt phosphorylation and PPAR beta/delta expression in the liver, reduced JNK1 phosphorylation and increased PGC1alpha expression in the muscle, and increased expression of IGF1 and insulin receptor in the heart are either related to mechanisms of CR action on longevity or represent potential biomarkers of delayed aging
Hancock et al., Proc Natl Acad Sci U S A 2008 (Body Weight...) : Similarly, overexpression of PPARdelta results in a large increase in PGC-1alpha protein in the absence of any increase in PGC-1alpha mRNA