◀ Back to PDGFB
MMP2 — PDGFB
Pathways - manually collected, often from reviews:
-
WikiPathways Angiogenesis:
PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2
→
PDGFB
(activation)
-
WikiPathways Angiogenesis:
PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2
→
MMP2/MMP9
(activation)
Text-mined interactions from Literome
Yang et al., Gastroenterology 2003
(Liver Cirrhosis) :
Stimulation of HSCs with
platelet derived growth factor (PDGF)-BB , transforming growth factor (TGF)-beta1, and/or epithelial growth factor (EGF)
resulted in an increase in their migratory capacity and up-regulated
matrix metalloproteinase (MMP)-2 activity
Risinger et al., J Biol Chem 2006
:
Although both
PDGF-BB and IGF-I stimulation
resulted in decreased smooth muscle alpha-actin expression and increased
matrix metalloproteinase (MMP)-2 expression, the response to IGF-I was significantly more rapid
Karakiulakis et al., J Biol Chem 2007
(Anoxia) :
PDGF-BB inhibited the synthesis and secretion of all hypoxia dependent
MMP via Erk1/2 mitogen activated protein ( MAP ) kinase activation
Liu et al., Neurol Res 2008
(Disease Models, Animal...) :
So,
PDGF-B may
induce the expression of
MMP for the degradation of collagen type III on the wall of the saccular aneurysms
Risinger et al., Am J Physiol Cell Physiol 2010
:
The regulation of
MMP-2 in
response to
PDGF-BB is complex and involves both stimulatory and inhibitory signaling pathways, resulting in a significant delay in upregulation