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ITGB1 — PDGFB

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ITGA2-ITGB1 → Complex of PDGFB-PDGFB (increases) Heldin et al., Physiol Rev 1999
  Evidence: On the other hand, PDGF simulates the synthesis of the collagen binding integrin alpha 2beta 1 (5, 246).

Text-mined interactions from Literome

Kagami et al., J Am Soc Nephrol 1999 (Disease Models, Animal) : Protein synthesis and mRNA analysis experiments demonstrated that TGF-beta, but not PDGF-BB , increases the expression of alpha1beta1 integrin in mesangial cells cultured on plastic surface and in collagen gels
Kagami et al., Biochem Biophys Res Commun 1998 : Immunoprecipitation using 35S-metabolic labeling, flow cytometry and a 3H-thymidine-uptake analysis demonstrated that PDGF-BB stimulated the cell mitogenicity and the expression of alpha5beta1 integrin ( a fibronectin receptor ), but not alpha1beta1 integrin ( a collagen and laminin receptor ) of MCs on plastic, in a dose dependent manner ... Immunoprecipitation using 35S-metabolic labeling, flow cytometry and a 3H-thymidine-uptake analysis demonstrated that PDGF-BB stimulated the cell mitogenicity and the expression of alpha5beta1 integrin ( a fibronectin receptor ), but not alpha1beta1 integrin ( a collagen and laminin receptor ) of MCs on plastic, in a dose dependent manner ... Thus, the parallel up-regulation of MC-mitogenicity and alpha5beta1 integrin expression by PDGF-BB suggested that alpha5beta1 integrin is an important ECM receptor involved in the proliferative phenotype of MC